DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp4a8

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	XP_038965258.1	Gene:	Cyp4a8 / 266674	RGDID:	628846	Length:	510	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	130/521 - (24%)
Similarity:	233/521 - (44%)	Gaps:	65/521 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVALLLIALAVGFWFVRTRYSYWTRRGIGSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKGNGA 68
            |:.:||:......:::..|:.....:...|.|:.:..|:...|..::.|.||:|.:  |...:..
  Rat    24 VLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFGHKLSFLVDQEFQDILTRV--KNFPSAC 86

  Fly    69 PFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFR------------I 121
            |...:...:|  :.|.|.:..|.||               .|.||.:.|.:|            :
  Rat    87 PQWLWGSNVR--IQVYDPDYMKLIL---------------GRSDPKSHHSYRFLAPWIGYGLLLL 134

  Fly   122 DGPKWRPLRQKMSPTFTSAKMK----YMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYT 182
            :|..|...|:.::|.|....:|    .|..:|..:.::..|:.|:  |:.    |||...:...|
  Rat   135 NGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQ--DST----LEIFQHITLMT 193

  Fly   183 SDVIGRCAFGVECNGLRNPEAEFAI-----MGRRAFSERRHCKLVDGFIESFPEVARFLRMR-QI 241
            .|.|.:|||..|.:...:.:.:..|     :...:|...|:....:..|.|.....|..|.. |:
  Rat   194 LDTIMKCAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQL 258

  Fly   242 HQDITDFYVGIVRETVKQREEQGIV----RSDFMNLLI--EMKQRGELTIEEMAAQAFIFFAAGF 300
            ..:.||..:...:..::..||...|    |.||:::|:  .::....|:.:::.|:...|...|.
  Rat   259 AHEHTDQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFARIENGSSLSDKDLRAEVDTFMFEGH 323

  Fly   301 DTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILP 365
            ||:||.:.:..|.||..|..|...|:|| |:|.......|:|.:.::.|..:.|.|.||.||.:.
  Rat   324 DTTASGISWIFYALATNPEHQQGCRKEI-QSLLGDGASITWDDLDKMPYTTMCIKEALRIYPPVT 387

  Fly   366 QLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWL 430
            .::|:..........|.  :..|..:::..||:||:|.::|.|..|.|.||..:  :.|.:.::|
  Rat   388 AVSRMLSTPVTFPDGRS--LPKGITVMLSFYGLHHNPTVWPNPEVFDPYRFAPE--SSRHSHSFL 448

  Fly   431 PFGDGPRNCIGMRFGKMQTTIGL-VSLLRNFHFSVCPRTDP-KIEFLKSNILLCPANGIYLKVQQ 493
            ||..|.|||||.:|...:..:.: ::|||   |.:.|  || :|......::|...|||||::::
  Rat   449 PFSGGARNCIGKQFAMNELKVAVALTLLR---FELLP--DPTRIPIPIPRLVLKSKNGIYLRLKK 508

  Fly   494 L 494
            |
  Rat   509 L 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	124/485 (26%)
Cyp4a8	XP_038965258.1	CYP4B-like	72..505	CDD:410771	120/467 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000