Protein Alignment Cyp6a22 and CYP4X1

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 136/528 - (25%)
• Similarity: 245/528 - (46%)
• Gaps: 78/528 - (14%)

  Fly     9 LIALAVGFWFVRTRYSYWTRRGIGSEPARFPVGNMEGFRKNKHFI-----DIVTPIYEKFK---- 64
            :..||:|  .::....|..|:.:..:...||......|..::.||     :.:..|.||:.
Human    19 VFCLALG--LLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFP 81

  Fly    65 ---GNGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGH-LFRIDGPK 125
               |   ||..||.:..|       :.||.:|    :..:.:..|..:...||.|. |..:||||
Human    82 FWIG---PFQAFFCIYDP-------DYAKTLL----SRTDPKSQYLQKFSPPLLGKGLAALDGPK 132

  Fly   126 WRPLRQKMSPTF----TSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVI 186
            |...|:.::|.|    ..|.::.|..:|..:.::..::| ...|.:    :|:.:.:...:.|:|
Human   133 WFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKIC-STQDTS----VEVYEHINSMSLDII 192

  Fly   187 GRCAFGVE--C--NGLRNPEAE-----FAIMGRRAFSERRHCKLVDGFIESFPEVARFLRMRQIH 242
            .:|||..|  |  |...:|.|:     ..|:..|.:|...|..::   .:..|:..||.::.::.
Human   193 MKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDII---FKLSPQGYRFQKLSRVL 254

  Fly   243 QDITDFYV---------GIVRETVKQREEQGIVRSDFMNLLIEMKQRGELTIEEMAAQAFI--FF 296
            ...||..:         |:.::...:|:.|     ||:::::..|.....:..::...:.:  |.
Human   255 NQYTDTIIQERKKSLQAGVKQDNTPKRKYQ-----DFLDIVLSAKDESGSSFSDIDVHSEVSTFL 314

  Fly   297 AAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKY 361
            .||.||.|:::.:.||.||..|..|.:.|||: :.:.......|:|.:.|:.|..:.|.||.|..
Human   315 LAGHDTLAASISWILYCLALNPEHQERCREEV-RGILGDGSSITWDQLGEMSYTTMCIKETCRLI 378

  Fly   362 PILPQLTR-ISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRP 425
            |.:|.::| :|:.|....|   ..:..|..:::.::|:||:||::..|..|.|.||..:...||.
Human   379 PAVPSISRDLSKPLTFPDG---CTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRH 440

  Fly   426 TAAWLPFGDGPRNCIGMRFG--KMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIY 488
            ..|:|||..|.|||||..|.  :::.||.|:.|    ||.|.|.....:.| .::.:|.|.||:|
Human   441 PYAYLPFSAGSRNCIGQEFAMIELKVTIALILL----HFRVTPDPTRPLTF-PNHFILKPKNGMY 500

  Fly   489 LKVQQLSQ 496
            |.:::||:
Human   501 LHLKKLSE 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	118/449 (26%)
CYP4X1	NP_828847.1	CYP4B-like	66..502	CDD:410771	123/471 (26%)
		heme binding region	447..460		7/12 (58%)