DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	148/521 - (28%)
Similarity:	254/521 - (48%)	Gaps:	65/521 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LDVVALLLIALAVGFWFVRTRYSYWTRRGIGSEPARFPV---GNMEGFRKNKHFIDIVTPIYEKF 63
            |.:...:|:|.::..:::...||:...:.:|. |...||   |.:..:.......|  ...|:|:
  Rat     7 LSIETWVLLATSLMLFYIYGTYSHGLFKKLGI-PGPKPVPLFGTIFNYGDGMWKFD--DDCYKKY 68

  Fly    64 KGNGAPFAGFFMMLRPVVLVTDLELAKQILIQD-FANFEDRGMYHNERDDPLTGHLFRIDGP--- 124
                ....||:...:|.:.:.|.|:.|.:|::: ::.|.:|                |..||
  Rat    69 ----GKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNR----------------RCFGPMGF 113

  Fly   125 -----------KWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLM 178
                       :|:.||..:||||||.|:|.|||.:.:.|:.|.:  ....:.|....:.:.|:.
  Rat   114 MKKAITMSEDEEWKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLK--NLRREEAKGEPINMKDIF 176

  Fly   179 ARYTSDVIGRCAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIES---FP---EVARFLR 237
            ..|:.|||...:|||..:.|.||:..|....::...    .::.|.|:.|   ||   .:...|.
  Rat   177 GAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILK----FQIFDPFLLSVVLFPFLTPIYEMLN 237

  Fly   238 MRQIHQDITDFYVGIVRETVKQR-EEQGIVRSDFMNLLIE-MKQRGE-----LTIEEMAAQAFIF 295
            .....:...:|:...|:...|.| :.....|.||:.|::. ...:|:     |:..||||||.||
  Rat   238 FSIFPRQSMNFFKKFVKTMKKNRLDSNQKSRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAIIF 302

  Fly   296 FAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRK 360
            ...|:|.:::::.|.:||||.:|.:|.||:.|||:||. :....|||::.|:.|:::|:.|:||.
  Rat   303 IFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALP-NKAPVTYDALMEMEYLDMVVNESLRL 366

  Fly   361 YPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRP 425
            |||..:|.|:|:......|   .:|..|.::.||:|.:|.:|..:.||.:|.||||..:......
  Rat   367 YPIATRLDRVSKKDVEING---VFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSID 428

  Fly   426 TAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLK 490
            ...:||||:||||||||||..:...:.::.:|:||:...|.:|...::..:..|.. |...|.||
  Rat   429 PYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLKISRQPIFQ-PEGPIILK 492

  Fly   491 V 491
            :
  Rat   493 L 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	141/486 (29%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	134/455 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870