Protein Alignment Cyp6a22 and Cyp17a1

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_036885.2
• Gene: Cyp17a1 / 25146
• RGDID: 2456
• Length: 507
• Species: Rattus norvegicus
• Alignment Length: 528
• Identity: 122/528 - (23%)
• Similarity: 214/528 - (40%)
• Gaps: 97/528 - (18%)

  Fly     1 MLDVVALLLIALAVGFWFVRTRYSYWTRRGIGSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKG 65
            |.::|.|||:.||..||...........|.:.|.|.   ||::....:..|.......:.||:
  Rat     1 MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPL---VGSLPFLPRRGHMHVNFFKLQEKY-- 60

  Fly    66 NGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNER--DDPLTGHLFRIDGPKWRP 128
              .|.....:.....|::...:||:::||:....|..|.....:.  .|...|..|...|..|..
  Rat    61 --GPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSSWHL 123

  Fly   129 LRQKMSPTFTSAKMKYMFPTVCEVGEELTQ-VCGELADNAMCGILEIGDLMARYTSDVIGR---- 188
            .|:.:..||:..|          .|::|.: :|.|.  .::|      |:|..:..:.|..
  Rat   124 HRKLVFSTFSLFK----------DGQKLEKLICQEA--KSLC------DMMLAHDKESIDLSTPI 170

  Fly   189 --------CAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVD-----GFIESFP---------- 230
                    ||.   |..:...:.:..:...:.|:|    .:||     ..::.||
  Rat   171 FMSVTNIICAI---CFNISYEKKDPKLTAIKTFTE----GIVDATGDRNLVDIFPWLTIFPNKGL 228

  Fly   231 EVAR-FLRMRQIHQDITDFYVGIVRETVKQREEQGIVRSDFMNLLIEMKQRGE------------ 282
            ||.: :.::|      .:...||..:..::.:.|.|  |...::||:.|...:
  Rat   229 EVIKGYAKVR------NEVLTGIFEKCREKFDSQSI--SSLTDILIQAKMNSDNNNSCEGRDPDV 285

  Fly   283 LTIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQEL 347
            .:...:.|.....|.||.:|:.:.|.:.|..|...|.::.|:::||||.:...... |::....|
  Rat   286 FSDRHILATVGDIFGAGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTP-TFNDRSHL 349

  Fly   348 RYMELVIAETLRKYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFI 412
            ..:|..|.|.||..|:.|.|.....::.::.|:  |.:.....:::.::.:|||...:.:|.:|:
  Rat   350 LMLEATIREVLRIRPVAPMLIPHKANVDSSIGE--FTVPKDTHVVVNLWALHHDENEWDQPDQFM 412

  Fly   413 PERFLADQLAQR---PTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSV-----CPRT- 468
            ||||| |.....   ||.::||||.|||:|||....:.:..:....||:.|...|     .||.
  Rat   413 PERFL-DPTGSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLE 476

  Fly   469 -DPKIEFL 475
             |||:.||
  Rat   477 GDPKVVFL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	105/463 (23%)
Cyp17a1	NP_036885.2	CYP17A1	60..490	CDD:410766	105/466 (23%)