DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	118/478 - (24%)
Similarity:	201/478 - (42%)	Gaps:	105/478 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 FAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFR------------ID 122
            |.||..:..|                |:|    :.:|  .|.||....::.            :|
  Rat    88 FVGFLNIYEP----------------DYA----KAVY--SRGDPKAADVYDFFLQWIGKGLLVLD 130

  Fly   123 GPKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCG----ELADNAMCGIL-EIGDLMARYT 182
            ||||...|:.::|.|....:|   |.|....|....:..    :.::|....|. ::|.:    .
  Rat   131 GPKWFQHRKLLTPGFHYDVLK---PYVAIFAESTRMMLDKWEKKASENKSFDIFCDVGHM----A 188

  Fly   183 SDVIGRCAFGVECNGL--RNPEAEFAIMGRRAFSERRHCKLVDGFIESF-----------PEVAR 234
            .|.:.:|.||...:||  |:.....|:.......::|        |:||           |...|
  Rat   189 LDTLMKCTFGKGDSGLGHRDNSYYLAVSDLTLLMQQR--------IDSFQYHNDFIYWLTPHGRR 245

  Fly   235 FLRMRQIHQDITDFYVGIVRETVKQR--------EEQGIVRS---DFMNLLIEMKQRG--ELTIE 286
            |||..:|..|.||       |.::||        |.:.|.:.   ||:::|:.::...  :|:..
  Rat   246 FLRACKIAHDHTD-------EVIRQRKAALQDEKERKKIQQRRHLDFLDILLGVRDESGIKLSDA 303

  Fly   287 EMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEI-----DQALRLHNGEFTYDSMQE 346
            |:.|:...|...|.||:.|.:.:.||.:|..|..|...|||:     ||      ..|.:|.:.:
  Rat   304 ELRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGDQ------DSFQWDDLAK 362

  Fly   347 LRYMELVIAETLRKYPILPQLTR-ISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHK 410
            :.|:.:.:.|..|.||.:||:.| :::.:....|..   :..|.::.:.:|.:|.:..::|:|..
  Rat   363 MTYLTMCMKECFRLYPPVPQVYRQLNKPVTFVDGRS---LPAGSLISLHIYALHRNSTVWPDPEV 424

  Fly   411 FIPERFLADQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFL 475
            |.|.||..:..|.|...|::||..|||||||.:|...:..:.....|..|.||:.|   .|:...
  Rat   425 FDPLRFSPENAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSLDP---SKMPIK 486

  Fly   476 KSNILLCPANGIYLKVQQLSQMS 498
            ...::|...|||:|.::.|:..|
  Rat   487 VPQLILRSKNGIHLYLKPLASRS 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	116/469 (25%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	115/467 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000