DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp6a16

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	505	Identity:	231/505 - (45%)
Similarity:	331/505 - (65%)	Gaps:	28/505 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LDVVALLLIALAVGF--WFVRTRYSYWTRRGIGSEPARFPVGNMEGFR-KNKHFIDIVTPIYEKF 63
            :|...|||.:| :.|  .::|.|::||..|||......|..|:.  || ::.|:.:::...|:.|
  Fly     1 MDFTLLLLTSL-LSFLLGYLRYRFTYWELRGIPQLRPHFLFGHF--FRLQSVHYSELLQETYDAF 62

  Fly    64 KGNGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFRIDGPKWRP 128
            :|: |..||.::.|||:.:|.||:|.|.:||:||.||.||..:|.   ||||.:||.:.|.:||.
  Fly    63 RGS-AKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHG---DPLTANLFNLQGEEWRN 123

  Fly   129 LRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCAFGV 193
            ||.|:||||||.||||||.||..|.::|.....||. .:...:||:.|||||||:||||.||||.
  Fly   124 LRTKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDELV-GSQGAVLELHDLMARYTTDVIGSCAFGT 187

  Fly   194 ECNGLRNPEAEFAIMGRRAF--SER----RHCKLVDGFIESFPEVARFLRMRQIHQDITDFYVGI 252
            ||:.||.|:|||..:|||.|  |.|    |..|:.  ::.|..::.  |.:|.:|.|||.|:..|
  Fly   188 ECSSLREPQAEFRQVGRRIFRNSNRSIRWRIFKMT--YLSSLAKLG--LPVRILHPDITKFFNRI 248

  Fly   253 VRETVKQREEQGIVRSDFMNLLIEMKQRGE---LTIEEMAAQAFIFFAAGFDTSASTLGFALYEL 314
            |||||:.||.:.|.|:|||:||::::::..   ||:|:||||||:||.|||:||:|.:.:||:||
  Fly   249 VRETVELRERENIRRNDFMDLLLDLRRQENGKGLTMEQMAAQAFVFFVAGFETSSSNMSYALFEL 313

  Fly   315 AKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTRISRHLY---A 376
            ||...:|.|||.||:.::..| |:.||::|.|:.|::..|.|||||||.|..|||::...|   :
  Fly   314 AKNQDVQQKLRMEINDSIGKH-GKLTYEAMMEMPYLDQTITETLRKYPALSSLTRLASEDYEIPS 377

  Fly   377 AKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGDGPRNCIG 441
            ..|.....:|.|..:.|||..||:||.:|||||:|.||||..|...:|...|:|.||||||||||
  Fly   378 PDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGDGPRNCIG 442

  Fly   442 MRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKV 491
            :|||:||..:||::|||.|.||:.|.:..:::..|.|::|.|::|:.|:|
  Fly   443 LRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRLQV 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	217/468 (46%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	217/471 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	8.070