Protein Alignment Cyp6a22 and cyp-25A1

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_497775.3
• Gene: cyp-25A1 / 183247
• WormBaseID: WBGene00007963
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 509
• Identity: 136/509 - (26%)
• Similarity: 249/509 - (48%)
• Gaps: 46/509 - (9%)

  Fly     4 VVALLLIALAVGFWFV----RTRYSYWTRRGI-GSEPARFPVGNME--GFRKNKHFIDIV----T 57
            :::.|:|::...|.::    |.|:....:.|: |.||..| :||::  ..||.|...|..    .
 Worm     5 ILSSLVISIFTFFIYIILARRERFKLREKIGLSGPEPHWF-LGNLKQTAERKEKLGYDDANRWFN 68

  Fly    58 PIYEKFKGNGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFRID 122
            .::|::   |..|..::.....:|:..:.:: |::.|::|:||.||.:......:.||..|....
 Worm    69 ELHEQY---GETFGIYYGSQMNIVISNEKDI-KEVFIKNFSNFSDRSVPSIYEANQLTASLLMNS 129

  Fly   123 -GPKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVI 186
             ...|:..|..::|.|::.|||.|..|:....:....:..|.|.:..  ..:|.|.....|.|||
 Worm   130 YSSGWKHTRSAIAPIFSTGKMKAMQETINSKVDLFLDILREKASSGQ--KWDIYDDFQGLTLDVI 192

  Fly   187 GRCAFGVECNGLRNPEAEFAIMGRRAFS--ERRHCKLVDGFIESFPEVARFLRMRQIHQDITDFY 249
            |:|||.::.|..|:....|.:..::..|  :.||.|::...: ..||::.|.:....:..:.|..
 Worm   193 GKCAFAIDSNCQRDRNDVFYVNAKKYISNIDIRHSKIIAASV-LLPELSTFWKALYKYTPLADAE 256

  Fly   250 V----GIVRETVKQREEQGIVRSDFMNLLI--EMKQRGELTIEEMAAQAFIFFAAGFDTSASTLG 308
            :    |:.....::|..:|....|.:.||:  |..:...:|.:|:....|.|..||::|:::.:.
 Worm   257 IPLVEGLSNVYERRRGGEGSDSVDLLKLLLNREDDKSKPMTKQEVIENCFAFLLAGYETTSTAMT 321

  Fly   309 FALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKY-PILPQLTRISR 372
            :..|.|:|.|.:|.||.|||.:|  ..||..||||:..::|::.|..||||.| |::..:.|:.|
 Worm   322 YCSYLLSKYPNVQQKLYEEIMEA--KENGGLTYDSIHNMKYLDCVYKETLRFYPPVIHFIRRLCR 384

  Fly   373 HLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTA-AWLPFGDGP 436
            .....:|  .||.:...::.:| :.:|.:|..:..|.:|.||||  :...::.:: .|:|||.||
 Worm   385 EDITIRG--QFYPKGAIVVCLP-HTVHRNPENWDSPEEFHPERF--ENWEEKSSSLKWIPFGVGP 444

  Fly   437 RNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLK 490
            |.|:||||.:|:....:|.||..|...         :|.....|:...||:.::
 Worm   445 RYCVGMRFAEMEFKTTIVKLLDTFELK---------QFEGEADLIPDCNGVIMR 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	119/432 (28%)
cyp-25A1	NP_497775.3	CYP3A-like	73..495	CDD:410678	119/440 (27%)