Protein Alignment Cyp6a22 and Cyp3a9

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_671739.2
• Gene: Cyp3a9 / 171352
• RGDID: 708392
• Length: 503
• Species: Rattus norvegicus
• Alignment Length: 528
• Identity: 158/528 - (29%)
• Similarity: 256/528 - (48%)
• Gaps: 91/528 - (17%)

  Fly     7 LLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKGNGAPF 70
            ||:|:|.:.:.:....:..:.:.|| |.:|..| :|.:..:||.  |.:.....::|:    ...
  Rat    14 LLVISLVLLYLYGTHSHGIFKKLGIPGPKPLPF-LGTILAYRKG--FWEFDKYCHKKY----GKL 71

  Fly    71 AGFFMMLRPVVLVTDLELAKQILIQD-FANFEDRGMYHNERDDPLTGHLFRI----DGPKWRPLR 130
            .|.:...:||:.:||.::.|.:|::: ::.|.      |.|:....|.|.:.    :..:|:.:|
  Rat    72 WGLYDGRQPVLAITDPDIIKTVLVKECYSTFT------NRRNFGPVGILKKAISISEDEEWKRIR 130

  Fly   131 QKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILE-----IGDLMARYTSDVIGRCA 190
            ..:||||||.|:|.|||.:       .|....|..|...|..|     :.|:...|:.|||...:
  Rat   131 ALLSPTFTSGKLKEMFPII-------NQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVITATS 188

  Fly   191 FGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIESFPEVARF-------------------- 235
            |||..:.|.||:                    |.|:|...::.:|
  Rat   189 FGVNVDSLNNPQ--------------------DPFVEKIKKLLKFDIFDPLFLSVTLFPFLTPLF 233

  Fly   236 --LRMRQIHQDITDFY---VGIVRET-VKQREEQGIVRSDFMNLLIEMK------QRGELTIEEM 288
              |.:....:|:.||:   |..::|. :|::|:|   |.||:.|:|..:      ....|:..|:
  Rat   234 EALNVSMFPRDVIDFFKTSVERMKENRMKEKEKQ---RMDFLQLMINSQNSKVKDSHKALSDVEI 295

  Fly   289 AAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELV 353
            .||:.||..||::|::|.|.|.||.||..|.:|.||::|||.||. :....|||::.::.|:::|
  Rat   296 VAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALP-NKAHATYDTLLQMEYLDMV 359

  Fly   354 IAETLRKYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLA 418
            :.||||.|||..:|.|:.:......|   .:|..|.:::||.:.:|.||..:|||.:|.||||..
  Rat   360 VNETLRLYPIAGRLERVCKTDVEING---VFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSK 421

  Fly   419 DQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCP 483
            ..........:||||:||||||||||..|...:.||.:|:||.|..|..|...::..|.. ||.|
  Rat   422 KNQDNINPYMYLPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKETQIPLKLSKQG-LLQP 485

  Fly   484 ANGIYLKV 491
            ...:.|||
  Rat   486 EKPLLLKV 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	141/463 (30%)
Cyp3a9	NP_671739.2	CYP3A	67..492	CDD:410743	142/469 (30%)