Protein Alignment Cyp6a22 and CYP27B1

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_000776.1
• Gene: CYP27B1 / 1594
• HGNCID: 2606
• Length: 508
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 113/423 - (26%)
• Similarity: 178/423 - (42%)
• Gaps: 75/423 - (17%)

  Fly   113 PLTGH---------LFRIDGPKWRPLRQKMSPTF--TSAKMKY---MFPTVCEVGEELTQVCGEL 163
            |.|.|         |...:|.:|:.||..::|..  ..|..:|   :...||::...|.:..|.
Human   112 PWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGR- 175

  Fly   164 ADNAMCGILEIGDLMARYTSDVIGR-CAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIE 227
                       |........||.|. ..||:|  |:    |...:..|....|.:.....:.||.
Human   176 -----------GTGPPALVRDVAGEFYKFGLE--GI----AAVLLGSRLGCLEAQVPPDTETFIR 223

  Fly   228 SFPE--VARFLRMRQIH--------------QDITDFYVGIVRETVKQREEQGIVRSDFMNLLIE 276
            :...  |:..|.|...|              :| .|......:..|::||.:..:|:...... :
Human   224 AVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRD-WDQMFAFAQRHVERREAEAAMRNGGQPEK-D 286

  Fly   277 MKQRGELT----IEEMAAQAFI-----FFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQAL 332
            ::....||    .||:.||:.:     ...||.||.::||.:|||||::.|.:|..|..||..|
Human   287 LESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAA- 350

  Fly   333 RLHNGEFTYDS---MQELRYMELVIAETLRKYPILPQLTRI-SRHLYAAKGDRHFYIEPGQMLL- 392
             |..|...|.|   :.:|..::.|:.|.||.||::|..:|: .:.::.  ||   ||.|...|:
Human   351 -LSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHV--GD---YIIPKNTLVT 409

  Fly   393 IPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLL 457
            :..|....|||.:|||:.|.|.|:|.:.....|.|: ||||.|.|:|:|.|..:::..:.|..:|
Human   410 LCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFAS-LPFGFGKRSCMGRRLAELELQMALAQIL 473

  Fly   458 RNFHFSVCPRTDPKIEFLKSNILLCPANGIYLK 490
            .  ||.|.|.........|:..:|.|...|.|:
Human   474 T--HFEVQPEPGAAPVRPKTRTVLVPERSINLQ 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	111/419 (26%)
CYP27B1	NP_000776.1	CYP27B1	68..503	CDD:410741	112/420 (27%)