Protein Alignment Cyp6a22 and CYP27A1

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_000775.1
• Gene: CYP27A1 / 1593
• HGNCID: 2605
• Length: 531
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 107/474 - (22%)
• Similarity: 190/474 - (40%)
• Gaps: 42/474 - (8%)

  Fly    43 MEGFRKNKHFIDIVTPIYEKFKGNGAPFAGFFMMLRPVVLVTDLELAKQILIQD--FANFEDRGM 105
            ::|:....|.:.::      :|....|....::..:..|.:....|.:|::.|:  :....|..:
Human    74 VQGYALQLHQLQVL------YKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMEL 132

  Fly   106 YHNERDD-PLTGHLFRIDGPKWRPLRQKMSPTFTS-AKMKYMFPTVCEVGEELTQVCGELADNAM 168
            :...||. .||...|..:|..|..|||.::..... |:.........||.::......:|...:.
Human   133 WKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESA 197

  Fly   169 CG--ILEIGDLMARYTSDVIGRCAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIESF-- 229
            .|  :.::..|...:..:.|....|......|:....|..:...|:........|...|:..:
Human   198 SGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTR 262

  Fly   230 PEVARFLRMRQIHQDITDFYVGIVRETVKQREEQ-------GIVRSDFMNLLIEMKQRGELTIEE 287
            |.:..:.|.......|..|...::.|.::..|.|       ||..|.:::.|:   ..|:|:..|
Human   263 PVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLL---ASGQLSPRE 324

  Fly   288 MAAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEF-TYDSMQELRYME 351
            ..........||.||:::||.:|||.|:|.|.:|..|.||:...:..  |:. .:.....:..::
Human   325 AMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPA--GQVPQHKDFAHMPLLK 387

  Fly   352 LVIAETLRKYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERF 416
            .|:.||||.||::|..:||........|   |........:...|.:..||..:.||..|.|.|:
Human   388 AVLKETLRLYPVVPTNSRIIEKEIEVDG---FLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRW 449

  Fly   417 L-----ADQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLK 476
            |     |....|.|..: :|||.|.|.|:|.|..:::..:.|..|::.:...:.|.|..    ||
Human   450 LRNSQPATPRIQHPFGS-VPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGE----LK 509

  Fly   477 S--NILLCPANGIYLKVQQ 493
            |  .|:|.|...:.|:..|
Human   510 SVARIVLVPNKKVGLQFLQ 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	102/444 (23%)
CYP27A1	NP_000775.1	cytochrome_P450	89..524	CDD:477761	103/447 (23%)
		Sterol-binding. /evidence=ECO:0000255	384..398		5/13 (38%)