DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and CYP3A5

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens

Alignment Length:	507	Identity:	159/507 - (31%)
Similarity:	253/507 - (49%)	Gaps:	50/507 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLIALAVGFWFVRTRYSYWTRRGIGSEPARFP-VGNMEGFRKNKHFIDIVTPIYEKFKGNGAPF 70
            ||.::|.:.:.:....:..:.|.||.. |...| :||:..:|:.....|  |..|:|:......:
Human    14 LLAVSLVLLYLYGTRTHGLFKRLGIPG-PTPLPLLGNVLSYRQGLWKFD--TECYKKYGKMWGTY 75

  Fly    71 AGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGH----LFRIDGPKWRPLRQ 131
            .|..    ||:.:||.::.:.:|::     |...::.|.|.....|.    :...:..:|:.:|.
Human    76 EGQL----PVLAITDPDVIRTVLVK-----ECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRS 131

  Fly   132 KMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCAFGVECN 196
            .:||||||.|:|.|||.:.:.|:.|.:.....|:......|:  |:...|:.|||...:|||..:
Human   132 LLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLK--DIFGAYSMDVITGTSFGVNID 194

  Fly   197 GLRNPEAEFAIMGRRAFSERRHCKLVDGFIES-------FP---EVARFLRMRQIHQDITDFYVG 251
            .|.||:..|      ..|.::..|.  ||::.       ||   .|...|.:....:|..:|...
Human   195 SLNNPQDPF------VESTKKFLKF--GFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSK 251

  Fly   252 IVRETVKQR-EEQGIVRSDFMNLLIEMKQRGE------LTIEEMAAQAFIFFAAGFDTSASTLGF 309
            .|....|.| .::...|.||:.|:|:.:...|      |:..|:|||:.||..||::|::|.|.|
Human   252 SVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSF 316

  Fly   310 ALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTRISRHL 374
            .|||||..|.:|.||::|||..|. :....|||::.::.|:::|:.||||.:|:..:|.|..:..
Human   317 TLYELATHPDVQQKLQKEIDAVLP-NKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKD 380

  Fly   375 YAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGDGPRNC 439
            ....|   .:|..|.|::||.|.:||||..:.||.:|.||||...:.:..| ..:.|||.|||||
Human   381 VEING---VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDP-YIYTPFGTGPRNC 441

  Fly   440 IGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKV 491
            |||||..|...:.|:.:|:||.|..|..|...:: |.:..||.|...|.|||
Human   442 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK-LDTQGLLQPEKPIVLKV 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	151/477 (32%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	151/480 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820