Protein Alignment Cyp6a22 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_001286431.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 159/509 - (31%)
• Similarity: 258/509 - (50%)
• Gaps: 51/509 - (10%)

  Fly     7 LLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKGNGAPF 70
            ||.::|.:.:.:....:..:.:.|| |..|..| :||:..:.|.....|:     |..|..|..:
Human    14 LLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPF-LGNILSYHKGFCMFDM-----ECHKKYGKVW 72

  Fly    71 AGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFR----IDGPKWRPLRQ 131
             ||:...:||:.:||.::.|.:|::     |...::.|.|.....|.:..    .:..:|:.||.
Human    73 -GFYDGQQPVLAITDPDMIKTVLVK-----ECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS 131

  Fly   132 KMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCG-ILEIGDLMARYTSDVIGRCAFGVEC 195
            .:||||||.|:|.|.|.:.:.|:.|.:   .|...|..| .:.:.|:...|:.|||...:|||..
Human   132 LLSPTFTSGKLKEMVPIIAQYGDVLVR---NLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNI 193

  Fly   196 NGLRNPEAEFAIMGRRAFSERRHCKLVDGF---IESFPEVARFLRMRQI---HQDITDFYVGIVR 254
            :.|.||:..|....::..    ....:|.|   |..||.:...|.:..|   .:::|:|    :|
Human   194 DSLNNPQDPFVENTKKLL----RFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNF----LR 250

  Fly   255 ETVKQREEQGIV-----RSDFMNLLIEMKQRGE------LTIEEMAAQAFIFFAAGFDTSASTLG 308
            ::||:.:|..:.     |.||:.|:|:.:...|      |:..|:.||:.||..||::|::|.|.
Human   251 KSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315

  Fly   309 FALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTRISRH 373
            |.:||||..|.:|.||:||||..|. :....|||::.::.|:::|:.||||.:||..:|.|:.:.
Human   316 FIMYELATHPDVQQKLQEEIDAVLP-NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKK 379

  Fly   374 LYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGDGPRN 438
            .....|   .:|..|.:::||.|.:|.||..:.||.||:||||............:.|||.||||
Human   380 DVEING---MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441

  Fly   439 CIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKVQ 492
            ||||||..|...:.|:.:|:||.|..|..|...:: |....||.|...:.|||:
Human   442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK-LSLGGLLQPEKPVVLKVE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	151/477 (32%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	152/481 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920