Protein Alignment Cyp6a22 and CYP2E1

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_000764.1
• Gene: CYP2E1 / 1571
• HGNCID: 2631
• Length: 493
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 129/546 - (23%)
• Similarity: 213/546 - (39%)
• Gaps: 165/546 - (30%)

  Fly     5 VALLLIA---LAVGFWFVRTRYSYWTRRGIGSEPARFP---VGNMEGFR---KN--KHFIDIVTP 58
            ||||:.|   |.|..|  |..:|.|     ...|..||   :||:  |:   ||  |.|    |.
Human     8 VALLVWAAFLLLVSMW--RQVHSSW-----NLPPGPFPLPIIGNL--FQLELKNIPKSF----TR 59

  Fly    59 IYEKFKGNGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRG---MYHNERDDPLTGHLFR 120
            :.::|    .|....::..:.:|::...:..|:.|:.....|..||   .:|..||   .|.:|.
Human    60 LAQRF----GPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRD---RGIIFN 117

  Fly   121 IDGPKWRPLRQKMSPTFTSAKMKYMFPTVCEVG------------------EELTQVCGE----- 162
             :||.|:.:|            ::...|:...|                  |.|.:..|:
Human   118 -NGPTWKDIR------------RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPT 169

  Fly   163 -LADNAMCGILEIGDLMARYTSDVIGRCAFGVECNGLRNPEAEFAIMGRRAFSERRH------CK 220
             |...|.|.:  |.|::.|...|.              |.|....:|  ..|:|..|      .:
Human   170 FLIGCAPCNV--IADILFRKHFDY--------------NDEKFLRLM--YLFNENFHLLSTPWLQ 216

  Fly   221 LVDGF--------------IESFPEVARFL--RMRQIHQ--------DITDFYVGIVRETVKQRE 261
            |.:.|              |::..||..::  |:::.||        |:||.
Human   217 LYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDC------------- 268

  Fly   262 EQGIVRSDFMNLLIEMKQRGE-----LTIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQ 321
                       ||:||::...     .|::.:.......|.||.:|:::||.:.|..|.|.|.::
Human   269 -----------LLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322

  Fly   322 AKLREEIDQAL---RLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTRISRHLYAAKGDRHF 383
            .||.||||:.:   |:.    .....||:.||:.|:.|..|...::|     |...:.|..|..|
Human   323 EKLHEEIDRVIGPSRIP----AIKDRQEMPYMDAVVHEIQRFITLVP-----SNLPHEATRDTIF 378

  Fly   384 --YIEPGQMLLIPVY-GIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGDGPRNCIGMRFG 445
              |:.|...:::|.. .:.:|...:|:|.||.||.||.:....:.:..:.||..|.|.|.|....
Human   379 RGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLA 443

  Fly   446 KMQTTIGLVSLLRNFHFSVCPRTDPK 471
            :|:..:.|.::|:  ||::.|..|||
Human   444 RMELFLLLCAILQ--HFNLKPLVDPK 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	106/474 (22%)
CYP2E1	NP_000764.1	CYP2C-like	64..487	CDD:410758	107/477 (22%)