DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a22 and CYP3A7

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_000756.3	Gene:	CYP3A7 / 1551	HGNCID:	2640	Length:	503	Species:	Homo sapiens

Alignment Length:	527	Identity:	160/527 - (30%)
Similarity:	256/527 - (48%)	Gaps:	63/527 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLIALAVGFWFVRT-----RYSYWTRR-------GI-GSEPARFPVGNMEGFRKNKHFIDIVTPI 59
            |:..|||..|.:..     .|.|.||.       || |..|..| :||...|||.....|:  ..
Human     3 LIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPF-LGNALSFRKGYWTFDM--EC 64

  Fly    60 YEKFKGNGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFR---- 120
            |:|::    ...|.:...:|::.:||.::.|.:|::     |...::.|.|.....|.:..
Human    65 YKKYR----KVWGIYDCQQPMLAITDPDMIKTVLVK-----ECYSVFTNRRPFGPVGFMKNAISI 120

  Fly   121 IDGPKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCG-ILEIGDLMARYTSD 184
            .:..:|:.:|..:||||||.|:|.|.|.:.:.|:.|.:   .|...|..| .:.:..:...|:.|
Human   121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVR---NLRREAETGKPVTLKHVFGAYSMD 182

  Fly   185 VIGRCAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIES---FPEVARFLRMRQIHQDIT 246
            ||...:|||..:.|.||:..|....::..    ....:|.|:.|   ||.:...|..    .:||
Human   183 VITSTSFGVSIDSLNNPQDPFVENTKKLL----RFNPLDPFVLSIKVFPFLTPILEA----LNIT 239

  Fly   247 DF---YVGIVRETVKQREEQGIV-----RSDFMNLLIEMKQRGE------LTIEEMAAQAFIFFA 297
            .|   .:..:.::|||.:|..:.     |.||:.|:|:.:...:      |:..|:.||:.||..
Human   240 VFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIF 304

  Fly   298 AGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYP 362
            ||::|::|.|.|.:||||..|.:|.|:::|||..|. :....|||::.:|.|:::|:.||||.:|
Human   305 AGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLP-NKAPPTYDTVLQLEYLDMVVNETLRLFP 368

  Fly   363 ILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTA 427
            :..:|.|:.:......|   .:|..|.:::||.|.:||||..:.||.||:||||...........
Human   369 VAMRLERVCKKDVEING---MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPY 430

  Fly   428 AWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKVQ 492
            .:.|||.||||||||||..:...:.||.:|:||.|..|..|...:: |:...||.....|.||.:
Human   431 IYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLK-LRFGGLLLTEKPIVLKAE 494

  Fly   493 QLSQMSS 499
            ...:..|
Human   495 SRDETVS 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	146/477 (31%)
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	146/480 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920