DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp4a10

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus

Alignment Length:	526	Identity:	137/526 - (26%)
Similarity:	234/526 - (44%)	Gaps:	83/526 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLIALAVGFWFVRTRYSYWTRRG---IGSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKGNGA 68
            |||:..||.|:..|    .|..:.   ..|.|..:..|: |.|:.::...:||:.| |.|.   :
Mouse    28 LLLLVKAVQFYLHR----QWLLKAFQQFPSPPFHWFFGH-EKFKGDQELQEIVSCI-ENFP---S 83

  Fly    69 PFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFR------------I 121
            .|..:|...:..:.|.|.:..|.||               .|.||.....:|            :
Mouse    84 AFPRWFWGSKAYLTVYDPDYMKVIL---------------GRSDPKANGAYRLLAPWIGYGLLLL 133

  Fly   122 DGPKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGE---LADNAMCGILEIGDLMARYTS 183
            :|..|...|:.::|.|....:|   |.|..:.:.:..:..:   |||..  ..:||...::..|.
Mouse   134 NGQPWFQHRRMLTPAFHYDILK---PYVKNMADSIRLMLDKWERLADQD--SSIEIFQHISLMTL 193

  Fly   184 DVIGRCAF----GVECNGLRNPEAEFAIMG--RRAFSER-RHCKLVDGFIESFPEVARFLRMR-Q 240
            |.:.:|||    .|:.:|  |.......:|  ...|..| |:....:..|.......|..:.. |
Mouse   194 DTVMKCAFSHKGSVQVDG--NYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAKQACQ 256

  Fly   241 IHQDITDFYVGIVRETVKQREEQGIV-------RSDFMNLLI--EMKQRGELTIEEMAAQAFIFF 296
            :..|.||   |:::....|.:::|.:       |.||:::|:  .|:....::.:::.|:...|.
Mouse   257 LAHDHTD---GVIKLRKDQLQDEGELEKIKKKRRLDFLDILLFARMENGDSMSDKDLRAEVDTFM 318

  Fly   297 AAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKY 361
            ..|.||:||.:.:..|.||..|..|.:.|||: |:|.......|:|.:.::.|..:.|.|.||.|
Mouse   319 FEGHDTTASGVSWIFYALATHPDHQQRCREEV-QSLLGDGSSITWDHLDQIPYTTMCIKEALRLY 382

  Fly   362 PILPQLTR-ISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRP 425
            |.:|.:.| :|..:....|..   :..|..:.:.:||:||:|.::|.|..|.|.||..|  :.|.
Mouse   383 PPVPGIVRELSTSVTFPDGRS---LPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPD--SPRH 442

  Fly   426 TAAWLPFGDGPRNCIGMRFGKMQ-TTIGLVSLLRNFHFSVCPRTDP-KIEFLKSNILLCPANGIY 488
            :.::|||..|.|||||.:|...: ..|..::|||   |.:.|  || ::....:.::|...||||
Mouse   443 SHSFLPFSGGARNCIGKQFAMSELKVIVALTLLR---FELLP--DPTRVPMPLARLVLKSKNGIY 502

  Fly   489 LKVQQL 494
            |.:::|
Mouse   503 LHLKKL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	127/490 (26%)
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	126/491 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000