Protein Alignment Cyp6a22 and Cyp3a16

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_031846.2
• Gene: Cyp3a16 / 13114
• MGIID: 106099
• Length: 504
• Species: Mus musculus
• Alignment Length: 532
• Identity: 162/532 - (30%)
• Similarity: 256/532 - (48%)
• Gaps: 88/532 - (16%)

  Fly     2 LDVVALLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKG 65
            ||.:.||.|.|.:.:.:....:..:.::|| |.:|..| :|.:..:.|.....|:  ..|||:..
Mouse     9 LDTLVLLAIILVLLYRYGTCTHGLFKKQGIPGPKPLPF-LGTVLNYYKGLWKFDM--ECYEKYGK 70

  Fly    66 NGAPFAGFFMMLRPVVLVTDLELAKQILIQD-FANFEDR------GMYHNE----RDDPLTGHLF 119
            ....|.|..    |:.::||.|..|.:|::: |:.|.:|      |:....    :|:
Mouse    71 TWGLFDGQI----PLFVITDPETIKNVLVKECFSVFTNRQDFFPVGIMSKSISLAKDE------- 124

  Fly   120 RIDGPKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSD 184
                 :|:..|..:||||||..:|.|||.:.:.|:.|.:...:.|:...  .:.:.|::..|:.|
Mouse   125 -----EWKRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKGK--PVAVKDVLGAYSMD 182

  Fly   185 VIGRCAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIESFPEVARF-------------- 235
            ||....|||..:.|.|||                    |.|:|:..:|.||
Mouse   183 VIISTTFGVNIDSLNNPE--------------------DPFVENAKKVLRFDYFDPLSLSVALFP 227

  Fly   236 --------LRMRQIHQDITDFYVGIV-RETVKQREEQGIVRSDFMNLLIEMKQRGE-------LT 284
                    |.:....:|..:|:...| |.|..:.:.:...|.||:.|::|...:.:       |:
Mouse   228 FLTPIYEMLNICMFPKDSIEFFKKFVDRMTENRLDSKQKHRVDFIYLMMEAYNKSKDKDSHKALS 292

  Fly   285 IEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRY 349
            ..|:.||:.||..||::|::|.|.|.:|.||..|.:|.||:||||:||. :....|||::..:.|
Mouse   293 EIEITAQSIIFIFAGYETTSSILSFTVYSLATHPDIQKKLQEEIDEALP-NKAPPTYDTVMAMEY 356

  Fly   350 MELVIAETLRKYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPE 414
            :::|:.||||.|||..:|.|:.:......|   .||..|..::||.|.:||||..:|||.:|.||
Mouse   357 LDMVLNETLRLYPITNRLQRVCKKDVEING---IYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPE 418

  Fly   415 RFLADQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNI 479
            ||..:.........:||||:||||||||||..|...:.|:.:|:||.|..|..|...:: |...:
Mouse   419 RFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQIPLK-LSREL 482

  Fly   480 LLCPANGIYLKV 491
            ||.|...|.|||
Mouse   483 LLQPVKPIVLKV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	141/462 (31%)
Cyp3a16	NP_031846.2	CYP3A	67..493	CDD:410743	143/468 (31%)