Protein Alignment Cyp6a22 and CYP4F8

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 138/526 - (26%)
• Similarity: 232/526 - (44%)
• Gaps: 66/526 - (12%)

  Fly     9 LIALAVGFWFVRTRYSYWTRRGI--GSEPARFPVGNMEGFRKNKHF---IDIVTPIYEKFKGNGA 68
            |:.|.||..::..|...||....  |.....||..     ||...|   :.:|||..|..:....
Human    20 LLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQP-----RKQNWFLGHLGLVTPTEEGLRVLTQ 79

  Fly    69 PFA----GFFMMLRPVVLVTDL---ELAKQILIQDFANFEDRGMYHNERDDPLTGH-LFRIDGPK 125
            ..|    ||...|.|:..:.:|   ::.:.::....| ..|:.:...:...|..|. |....|.|
Human    80 LVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDA-ITDKDIVFYKTLKPWLGDGLLLSVGDK 143

  Fly   126 WRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELA-DNAMCGILEIGDLMARYTSDVIGRC 189
            ||..|:.::|.|....:|.......:....:......|| :.:.|  |::.:.::..|.|.:.:|
Human   144 WRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTC--LDVFEHISLMTLDSLQKC 206

  Fly   190 AFGVECNGLRNPEAEF--AIMGRRAFSERRH---CKLVDGFIESFPEVARFLRMRQIHQDITDFY 249
            .|..:.|....| :|:  |||...|...:|:   .:..|......|...||.|..::..|.||
Human   207 IFSFDSNCQEKP-SEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTD-- 268

  Fly   250 VGIVRETVKQREEQGIVRSDFMN--------------LLIEMKQRGELTIEEMAAQAFIFFAAGF 300
             .:::|..:....||:  .||:.              ||.|.|...||:.|::.|:|..|...|.
Human   269 -AVIQERRRTLTSQGV--DDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGH 330

  Fly   301 DTSASTLGFALYELAKQPALQAKLREEIDQALR-LHNGEFTYDSMQELRYMELVIAETLRKYPIL 364
            ||:||.|.:.||.||:.|..|.:.|:|:.:.|: ....|..:|.:.:|.::.:.:.|:||.:|.:
Human   331 DTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPI 395

  Fly   365 PQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAW 429
            |...|...........|  .|..|.:..|.::.|||:|:::|:|..:.|.||..:...:|...|:
Human   396 PTFARGCTQDVVLPDSR--VIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAF 458

  Fly   430 LPFGDGPRNCIGMRFGKMQTTIGL-VSLLRNFHFSVC-----PRTDPKIEFLKSNILLCPANGIY 488
            :||..|||||||.:|...:..:.| ::|||   |.:.     ||..|:       |:|...:|::
Human   459 IPFSAGPRNCIGQKFAMAEMKVVLALTLLR---FRILPDHREPRRTPE-------IVLRAEDGLW 513

  Fly   489 LKVQQL 494
            |:|:.|
Human   514 LRVEPL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	118/456 (26%)
CYP4F8	NP_009184.1	CYP4F	74..515	CDD:410772	118/461 (26%)