Protein Alignment Cyp6a22 and Cyp3a59

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_001098630.1
• Gene: Cyp3a59 / 100041449
• MGIID: 3769707
• Length: 503
• Species: Mus musculus
• Alignment Length: 521
• Identity: 142/521 - (27%)
• Similarity: 258/521 - (49%)
• Gaps: 65/521 - (12%)

  Fly     2 LDVVALLLIALAVGFWFVRTRYSYWTRRGIG-SEPARFPV-GNMEGFRKNKHFIDIVTPIYEKFK 64
            |.:...:|:..::.|:::...||:...:.:| ..|...|: |.:..:.......|  ...|:|:
Mouse     7 LSIETWVLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGTIFNYFDGMWKFD--EDCYKKY- 68

  Fly    65 GNGAPFAGFFMMLRPVVLVTDLELAKQILIQD-FANFEDRGMYHNERDDPLTGHLFRI------- 121
               ....||::..:|::.:.|.|:.|.:|::: ::.|.:|         |..|.:..:
Mouse    69 ---GKIWGFYVGPKPILAIMDPEIIKIVLVKECYSVFTNR---------PTLGPVGFLKKSITIS 121

  Fly   122 DGPKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELT------QVCGELADNAMCGILEIGDLMAR 180
            :..:|:.||..:||||||.|:|.|||.:.:.|:.|.      :..||        .:.:.|:...
Mouse   122 EDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGE--------PINMKDIFGA 178

  Fly   181 YTSDVIGRCAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIES---FP---EVARFLRMR 239
            |:.|||...:|||..:.|.||:..|....::...    .|:.|.|:.|   ||   .:...|.:.
Mouse   179 YSMDVITGTSFGVNIDSLNNPQNPFVQKTKKILK----FKIFDPFLLSTILFPFLTPIYEMLNLS 239

  Fly   240 QIHQDITDFYVGIVRETVKQR---EEQGIVRSDFMNLLIE-MKQRGE-----LTIEEMAAQAFIF 295
            ...:|..:|:...|:...|:|   :::.  |.||:.|::. ...:|:     |:..||||||.||
Mouse   240 IFPRDSMNFFKKFVKRMKKERLASKQKN--RVDFLQLMMNTQNSKGQESQKALSDLEMAAQAVIF 302

  Fly   296 FAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRK 360
            ...|:|.:::::...:||||..|.:|.||::|||:.|. :....|||::.::.|:::|:.|:||.
Mouse   303 IFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLP-NKAPVTYDALMDMEYLDMVVNESLRL 366

  Fly   361 YPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRP 425
            ||...:|.|:|:......|   .:|..|.:::||:|.:|.:|..:|||.:|.|.||..:......
Mouse   367 YPTAIRLERVSKKDVEING---VFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENEGNID 428

  Fly   426 TAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLK 490
            ...::|||:|||||:.|||..:...:.::.:|:||....|..|...::..:..:.. |...|.||
Mouse   429 PYIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQIPLKISREPVFQ-PEKPIILK 492

  Fly   491 V 491
            |
Mouse   493 V 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	126/450 (28%)
Cyp3a59	NP_001098630.1	CYP3A	67..492	CDD:410743	128/456 (28%)