DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a22 and Cyp4a32

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001093651.1	Gene:	Cyp4a32 / 100040843	MGIID:	3717148	Length:	509	Species:	Mus musculus

Alignment Length:	526	Identity:	133/526 - (25%)
Similarity:	237/526 - (45%)	Gaps:	83/526 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLIALAVGFWFVRTRYSYWTRRGI---GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKGNGA 68
            |||:..||.|:..|.    |..:.:   .|.|..:..|: |.|:..:...::|:.| |.|.   :
Mouse    28 LLLLVKAVQFYLHRK----WLLKALQQFPSPPFHWFFGH-EQFKGEQELKEVVSCI-EHFP---S 83

  Fly    69 PFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFR------------I 121
            .|..:|......:.|.|.:..|.||               .|.||....::|            :
Mouse    84 AFPCWFWGSNAYLTVYDPDYMKVIL---------------GRSDPKANGIYRLLAPWIGYGLLLL 133

  Fly   122 DGPKWRPLRQKMSPTF----TSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYT 182
            :|..|...|:.::|.|    ....:|.|..::..:.::..::.|:  |::    :||...::..|
Mouse   134 NGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLAGQ--DSS----IEIFQHISLMT 192

  Fly   183 SDVIGRCAF----GVECNGLRNPEAEFAIMG--RRAFSER-RHCKLVDGFIESFPEVARFLRMR- 239
            .|.:.:|||    .|:.:|  |.:.....:|  ...|..| |:....:..|.......|..:..
Mouse   193 LDTVMKCAFSHKGSVQVDG--NYKTYLQAIGDLNNLFHSRVRNIFHQNDTIYRLSSNGRLAKQAC 255

  Fly   240 QIHQDITDFYVGIVRETVKQREEQGIV-------RSDFMNLLI--EMKQRGELTIEEMAAQAFIF 295
            |:..|.||   |:::....|.:::|.:       |.||:::|:  .|:....::.:::.|:...|
Mouse   256 QLAHDHTD---GVIKMRKDQLQDEGELENIKKKRRLDFLDILLFARMENGDSMSDKDLRAEVDTF 317

  Fly   296 FAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRK 360
            ...|.||:||.:.:..|.||..|..|.:.|||: |:|.......|:|.:.::.|..:.|.|.||.
Mouse   318 MFEGHDTTASGVSWIFYALATHPEHQQRCREEV-QSLLGDGSSITWDHLDQIPYTTMCIKEALRL 381

  Fly   361 YPILPQLTR-ISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQR 424
            ||.:|.:.| :|..:....|..   :..|..:.:.:||:||:|.::|.|..|.|.||..|  :.|
Mouse   382 YPPVPGIVRELSTSVTFPDGRS---LPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPD--SPR 441

  Fly   425 PTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDP-KIEFLKSNILLCPANGIY 488
            .:.::|||..|.|||||.:|.  .:.:.::..|...||.:.|  || ::....:.|:|...||||
Mouse   442 HSHSFLPFSGGARNCIGKQFA--MSELKVIVALTLLHFELLP--DPTRVPEPLARIVLKSKNGIY 502

  Fly   489 LKVQQL 494
            |.:::|
Mouse   503 LHLKKL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	123/490 (25%)
Cyp4a32	NP_001093651.1	p450	52..503	CDD:278495	122/491 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000