DRSC/TRiP Functional Genomics Resources

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Protein Alignment OPHN1 and RGA2

DIOPT Version :10

Sequence 1:NP_002538.1 Gene:OPHN1 / 4983 HGNCID:8148 Length:802 Species:Homo sapiens
Sequence 2:NP_010667.1 Gene:RGA2 / 851985 SGDID:S000002787 Length:1009 Species:Saccharomyces cerevisiae


Alignment Length:609 Identity:121/609 - (19%)
Similarity:220/609 - (36%) Gaps:201/609 - (33%)


- Green bases have known domain annotations that are detailed below.


Human     2 GH-------PPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQK 59
            ||       |||| |......|........:.....:|::....:::|.:..:.|....:::::|
Yeast   553 GHHIAMFRTPPLE-SGPLFKRPSLSSESAHHRSSSLQTSRSTNALLEDDSTKVDATDESATSLEK 616

Human    60 FSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQI 124
                    .|.|...||...::::.|......:||.:|||.|:     |.:.|:..::|..:|:.
Yeast   617 --------DFYFTELTLRKLKLDVRELEGTKKKLLQDVENLRL-----AKERLLNDVDNLTREKD 668

Human   125 GFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERH-NFFESSLDYVYQIQEV 188
            ..:...::..|:......|:..:....:|.:|.| :..|.   .|.|. ..|.|:.|  :|:.::
Yeast   669 KQSASSRESLEQKENIATSITVKSPSSNSDRKGS-ISNAS---PKPRFWKIFSSAKD--HQVGDL 727

Human   189 QESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRM 253
            :..::            |...|:..|..:.|                 ...||.:     |.:..
Yeast   728 ESQQR------------SPNSSSGGTTNIAQ-----------------KEISSPK-----LIRVH 758

Human   254 KEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTL 318
            .|.|...|:|..|:.:...||.:...|..|.::..|.|||.|                       
Yeast   759 DELPSPGKVPLSPSPKRLDYTPDGSHLYGSSLQARCAYEKST----------------------- 800

Human   319 KYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLWMEAMDGKEPIYHSPITKQQEMELN 383
                                                                 .||         
Yeast   801 -----------------------------------------------------VPI--------- 803

Human   384 EVGFKFVRKCINIIETK--GIKTEGLYRTVGSNIQVQKLLNAF----------FDPKCPGDVDFH 436
                 .:|.||:.||..  |:..|||||..||...|:::.|.|          ..||.       
Yeast   804 -----IIRCCIDRIEKDDIGLNMEGLYRKSGSQTLVEEIENEFAQNNSLHSDTLSPKL------- 856

Human   437 NS--DWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLG-------------AIH 486
            |:  :.||..:.|.||.|||.|.:||:::.::..|:...:::.|..||.             .|:
Yeast   857 NALLNQDIHAVASVLKRYLRKLPDPVLSFSIYDALIDLVRNNQLIERLPLNNDKFLDSPQKVTIY 921

Human   487 SLVYK--------LPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMR---AQEDTV 540
            .:|.|        ||.:::|:|::|..|:..|...|:.|||...|:.::|.|:|:.   .::|.|
Yeast   922 EMVLKSLLEIFKILPVEHQEVLKVLAAHIGKVRRCSERNLMNLHNLSLVFAPSLIHDFDGEKDIV 986

Human   541 AAMMNIKFQNIVVEILIEHFGKIY 564
                ::|.:|.:||.::.::..|:
Yeast   987 ----DMKERNYIVEFILGNYRDIF 1006

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OPHN1NP_002538.1 BAR_OPHN1 19..225 CDD:153317 35/206 (17%)
BAR-PH_GRAF_family 267..370 CDD:269953 9/102 (9%)
RhoGAP_Graf 363..559 CDD:239839 60/233 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 569..588
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 607..666
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 680..770
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 783..802
RGA2NP_010667.1 LIM1_Rga 13..67 CDD:188780
LIM2_Rga 70..123 CDD:188781
RhoGAP 815..1002 CDD:214618 53/197 (27%)
Blue background indicates that the domain is not in the aligned region.

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