Protein Alignment OPHN1 and ophn1

DIOPT Version :10

• Sequence 1: NP_002538.1
• Gene: OPHN1 / 4983
• HGNCID: 8148
• Length: 802
• Species: Homo sapiens
• Sequence 2: XP_073808471.1
• Gene: ophn1 / 436982
• ZFINID: ZDB-GENE-040718-464
• Length: 789
• Species: Danio rerio
• Alignment Length: 808
• Identity: 513/808 - (63%)
• Similarity: 598/808 - (74%)
• Gaps: 49/808 - (6%)

Human     1 MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKFSQTLQ 65
            |.||.|||||||.|||||||||||||.|||:||||:||||||||.:|:..:.||.||||||||||
Zfish     1 MVHPALEFSDCYSDSPDFRERLKCYENELEKTNKFLKDVIKDGNNVINTFKEYSLAVQKFSQTLQ 65

Human    66 SFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQIGFTKER 130
            |||||||||||||||:||||||:|||.||.:||..|||:|.|||||||||||.|||||||.||||
Zfish    66 SFQFDFIGDTLTDDEMNIAESFREFAGLLQDVEEARMMLVQNASDLLIKPLEKFRKEQIGVTKER 130

Human   131 KKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKFN 195
            :|||||:.|::||.||:|::|||||||:||||||.|:||||..|:|||::||||||:|||.|||:
Zfish   131 RKKFEKESEKYYSQLDKHVNLSSKKKETQLQEADEQLDKERQAFYESSVEYVYQIQQVQEKKKFD 195

Human   196 IVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTC 260
            :||||||||.|:...|:||||:|||||||||:||||||||||||.|||||||||.||||.:.:..
Zfish   196 VVEPVLAFLQSILTLNNLTVEMTQDFLPYKQELQLSLQNTRNHFESTREEMEELMKRMKGSAKIS 260

Human   261 KLPGQP-TIEGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRR 324
            ...||| |:|||||.|||||||::|||.||:|.|:.|...|.|||||.|.||....||||.|:||
Zfish   261 IRHGQPATMEGYLYVQEKWALGVTWVKNYCKYFKDNKLFIMVPMEQKAGIKQTTAQLTLKSCIRR 325

Human   325 KTESIDKRFCFDIETNERPGTITLQALSEANRRLWMEAMDGKEPIYHSPITKQQEMELNEVGFKF 389
            ||:|.||||||||||:||...:.|||:||.||:.|:||||||||||||||.||.|||||::||||
Zfish   326 KTDSTDKRFCFDIETSERGSPVLLQAISEVNRKQWIEAMDGKEPIYHSPIQKQAEMELNDLGFKF 390

Human   390 VRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLR 454
            ||||||.:||||:..||:|||||||||||||||||||.|||.||||::||.|||||||:||||||
Zfish   391 VRKCINFVETKGLTQEGVYRTVGSNIQVQKLLNAFFDSKCPADVDFNSSDMDIKTITSALKFYLR 455

Human   455 NLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLM 519
            :||||:|||.||.||:.||||:||||||||:|||||||||:|||||||||:|||:||.||.||||
Zfish   456 SLSEPLMTYSLHGELILAAKSENLDYRLGAVHSLVYKLPERNREMLELLIKHLVSVCSHSSENLM 520

Human   520 TPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTAR 584
            |.||||||||||||||:|:|||||::|||||||:|||||.:.||:.||||||..||||||||:.|
Zfish   521 TVSNMGVIFGPTLMRAEEETVAAMLDIKFQNIVMEILIEDYSKIFKGPPEESVPPPVPPPRVSPR 585

Human   585 RHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPNGTITSSIEP-----PKPPQHPKLPIQRSG 644
            |.:|||||||..|..|.....:.:..|       .||...::.||     |.|.|..||
Zfish   586 RRQPITISKRPARVYTGLQPPAFERRE-------LNGATHNNGEPEGDGGPVPQQRTKL------ 637

Human   645 ETDPGRKSPSRPILD----GKLEPCP-----EVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTK 700
             ..|....||.|:..    ..|.|.|     |.:|.:..:|:|||   :...||.....|....:
Zfish   638 -IPPSISPPSIPLSSPTSRRPLHPRPAVRLLEPEVSRFDARIQDG---LRSDATTNGDSGGTVNR 698

Human   701 TPSFHIKRPAPRPLAHHKEGDADSFSKVRPPGEKPTIIRPPVRPPDPPCRAATPQKPEPKPDIVA 765
            ..||. ||...:......:|     .|.|...||.:|.|||.||||||.|..:....|..|
Zfish   699 AQSFQ-KRTQLKGTTGEAQG-----LKRRSFSEKSSICRPPTRPPDPPSRLFSKPPNEDTP---- 753

Human   766 GNAGEITSSVVASRTRFFETASRKTGSS 793
                   .|.|||:|:|||.|||:.|||
Zfish   754 -------PSYVASKTKFFENASRQMGSS 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPHN1	NP_002538.1	BAR_OPHN1	19..225	CDD:153317	155/205 (76%)
		BAR-PH_GRAF_family	267..370	CDD:269953	68/102 (67%)
		RhoGAP_Graf	363..559	CDD:239839	160/195 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	569..588		13/18 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	607..666		16/67 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..770		26/89 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	783..802		8/11 (73%)
ophn1	XP_073808471.1	None