Protein Alignment Lgr6 and Lgr4

DIOPT Version :10

• Sequence 1: NP_001414286.1
• Gene: Lgr6 / 498233
• RGDID: 1560339
• Length: 965
• Species: Rattus norvegicus
• Sequence 2: NP_001285192.1
• Gene: Lgr4 / 5740505
• FlyBaseID: FBgn0085440
• Length: 809
• Species: Drosophila melanogaster
• Alignment Length: 862
• Identity: 210/862 - (24%)
• Similarity: 302/862 - (35%)
• Gaps: 268/862 - (31%)

  Rat    36 PAPCHCQEDGIMLSADCSELG-----LSEVPADLDPLTAYLDLSMNNLTELQP-GLFHHLRFLE- 93
            |...:|  ||   |.||.:..     ::||.|      .|.|    :|...|| |...:||..|
  Fly   104 PQRANC--DG---SVDCDDASDEVNCVNEVDA------KYWD----HLYRKQPFGRHDNLRIGEC 153

  Rat    94 --------------ELRLSGNHLSHIPRQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLR 144
                          |:......|:.||.:.  ..|.|..|.|..|....|......|||.:.||.
  Fly   154 LWPNENFSCPCRGDEILCRFQQLTDIPERL--PQHDLATLDLTGNNFETIHETFFSELPDVDSLV 216

  Rat   145 LDANLISLVPERSFEGLSS--LRHLWLDDNALTEIPVRALNNLPALQAMTLALNRIRHIPDYAFQ 207
            |....|..:...:|:.|:.  ||.|::|||.|..:|.........|..:.||.|.:.|:....|.
  Fly   217 LKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFL 281

  Rat   208 NLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNELQEFPVAIRTLGRLQELGFHNNNIKAI 272
            ||..|..|.|..|||.:.....|..|.|||.|.||.|.|:..
  Fly   282 NLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRL----------------------- 323

  Rat   273 PEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLSKLHTLSL--NGATDI--QEFPDLKGTTSLEIL 333
                              :|.:|.     :.|..||||||  |...||  ..||
  Fly   324 ------------------DPDRFP-----RTLLNLHTLSLAYNQIEDIAANTFP----------- 354

  Rat   334 TLTRAGIRLLPAGMCQQLPRLRILELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLS 398
                             .||||.|.|:                      .||:..|..:||..||
  Fly   355 -----------------FPRLRYLFLA----------------------GNRLSHIRDETFCNLS 380

  Rat   399 SLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKD 463
            :||.|.|:.|.|.....|||:.|::|..|.||.|:..||                         |
  Fly   381 NLQGLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTL-------------------------D 420

  Rat   464 SFPKLRILEVPYAYQCCAYGLCANFFKTSGQWQAEDFHAEEEEAPKRPLGLLAGQAENHYDLDLD 528
            |.....:..:.|.|               ..|    ||                         |.
  Fly   421 SRVLKNLTSLDYIY---------------FSW----FH-------------------------LC 441

  Rat   529 ELQMETEDSKPHPSVQCSPVPGPFKPCEHLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPSP 593
            ...|......||.....|.:        ||.::..:|.:||.:..::|:.|.||||..:......
  Fly   442 SAAMNVRVCDPHGDGISSKL--------HLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRS 498

  Rat   594 LSPVKLVVGAIAGANALTGISCGLLASVDALTFGQFAEYGARWETGLGCQATGFLAVLGSEASVL 658
            .....|.:..:|.::.|.||...|:|..|....|::.:|...|.....|...|||:....::|.|
  Fly   499 NVEHSLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTL 563

  Rat   659 LLTLAAVQCSVSVTCVRAYGKAPSPGSVRAGALGCLAL----AGLAAA--LPLASVGE--YGASP 715
            ||||......:|||  |.. |......||. .|..|.|    .|||||  ||....|.  ||.:.
  Fly   564 LLTLVTWDRLMSVT--RPL-KPRDTEKVRI-VLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNG 624

  Rat   716 LCL------PYAPPEGRPAALGF---AVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVWDC-- 769
            :||      |||.        |:   |:..:::|:|..:.:..:||::        .:|:.|.
  Fly   625 VCLSLHIHDPYAK--------GWEYSALLFILVNTLSLIFILFSYIRM--------LQAIRDSGG 673

  Rat   770 -----------AMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLN 823
                       .:....|.::..|...:.|:..:..|::.|. .::|:....:.::|||:.:.||
  Fly   674 GMRSTHSGRENVVATRFAIIVTTDCACWLPIIVVKLAALSGC-EISPDLYAWLAVLVLPVNSALN 737

  Rat   824 PLLYLLFNPHFREDLRR 840
            |:||.|....|::.|||
  Fly   738 PVLYTLTTAAFKQQLRR 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lgr6	NP_001414286.1	None
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:395011	7/24 (29%)
		LRR	167..>430	CDD:443914	97/385 (25%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		leucine-rich repeat	212..235	CDD:275380	6/22 (27%)
		leucine-rich repeat	238..261	CDD:275380	8/22 (36%)
		leucine-rich repeat	262..285	CDD:275380	8/22 (36%)
		leucine-rich repeat	286..309	CDD:275380	8/22 (36%)
		leucine-rich repeat	310..334	CDD:275380	10/69 (14%)
		leucine-rich repeat	335..357	CDD:275380	11/49 (22%)
		leucine-rich repeat	358..381	CDD:275380	10/44 (23%)
		leucine-rich repeat	382..405	CDD:275380	10/22 (45%)
		leucine-rich repeat	406..427	CDD:275380	9/45 (20%)
		7tmA_Relaxin_R	467..752	CDD:320265	79/305 (26%)
		TM helix 1	468..494	CDD:320265	9/25 (36%)
		TM helix 2	502..527	CDD:320265	7/24 (29%)
		TM helix 3	547..577	CDD:320265	11/29 (38%)
		TM helix 4	588..610	CDD:320265	10/22 (45%)
		TM helix 5	638..667	CDD:320265	6/36 (17%)
		TM helix 6	681..711	CDD:320265	3/29 (10%)
		TM helix 7	720..745	CDD:320265	9/24 (38%)