DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr6 and Lgr4

DIOPT Version :9

Sequence 1:	XP_573455.1	Gene:	Lgr6 / 498233	RGDID:	1560339	Length:	965	Species:	Rattus norvegicus
Sequence 2:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster

Alignment Length:	862	Identity:	210/862 - (24%)
Similarity:	302/862 - (35%)	Gaps:	268/862 - (31%)

- Green bases have known domain annotations that are detailed below.

  Rat    36 PAPCHCQEDGIMLSADCSELG-----LSEVPADLDPLTAYLDLSMNNLTELQP-GLFHHLRFLE- 93
            |...:|  ||   |.||.:..     ::||.|      .|.|    :|...|| |...:||..|
  Fly   104 PQRANC--DG---SVDCDDASDEVNCVNEVDA------KYWD----HLYRKQPFGRHDNLRIGEC 153

  Rat    94 --------------ELRLSGNHLSHIPRQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLR 144
                          |:......|:.||.:.  ..|.|..|.|..|....|......|||.:.||.
  Fly   154 LWPNENFSCPCRGDEILCRFQQLTDIPERL--PQHDLATLDLTGNNFETIHETFFSELPDVDSLV 216

  Rat   145 LDANLISLVPERSFEGLSS--LRHLWLDDNALTEIPVRALNNLPALQAMTLALNRIRHIPDYAFQ 207
            |....|..:...:|:.|:.  ||.|::|||.|..:|.........|..:.||.|.:.|:....|.
  Fly   217 LKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFL 281

  Rat   208 NLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNELQEFPVAIRTLGRLQELGFHNNNIKAI 272
            ||..|..|.|..|||.:.....|..|.|||.|.||.|.|:..
  Fly   282 NLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRL----------------------- 323

  Rat   273 PEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLSKLHTLSL--NGATDI--QEFPDLKGTTSLEIL 333
                              :|.:|.     :.|..||||||  |...||  ..||
  Fly   324 ------------------DPDRFP-----RTLLNLHTLSLAYNQIEDIAANTFP----------- 354

  Rat   334 TLTRAGIRLLPAGMCQQLPRLRILELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLS 398
                             .||||.|.|:                      .||:..|..:||..||
  Fly   355 -----------------FPRLRYLFLA----------------------GNRLSHIRDETFCNLS 380

  Rat   399 SLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKD 463
            :||.|.|:.|.|.....|||:.|::|..|.||.|:..||                         |
  Fly   381 NLQGLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTL-------------------------D 420

  Rat   464 SFPKLRILEVPYAYQCCAYGLCANFFKTSGQWQAEDFHAEEEEAPKRPLGLLAGQAENHYDLDLD 528
            |.....:..:.|.|               ..|    ||                         |.
  Fly   421 SRVLKNLTSLDYIY---------------FSW----FH-------------------------LC 441

  Rat   529 ELQMETEDSKPHPSVQCSPVPGPFKPCEHLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPSP 593
            ...|......||.....|.:        ||.::..:|.:||.:..::|:.|.||||..:......
  Fly   442 SAAMNVRVCDPHGDGISSKL--------HLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRS 498

  Rat   594 LSPVKLVVGAIAGANALTGISCGLLASVDALTFGQFAEYGARWETGLGCQATGFLAVLGSEASVL 658
            .....|.:..:|.::.|.||...|:|..|....|::.:|...|.....|...|||:....::|.|
  Fly   499 NVEHSLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTL 563

  Rat   659 LLTLAAVQCSVSVTCVRAYGKAPSPGSVRAGALGCLAL----AGLAAA--LPLASVGE--YGASP 715
            ||||......:|||  |.. |......||. .|..|.|    .|||||  ||....|.  ||.:.
  Fly   564 LLTLVTWDRLMSVT--RPL-KPRDTEKVRI-VLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNG 624

  Rat   716 LCL------PYAPPEGRPAALGF---AVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVWDC-- 769
            :||      |||.        |:   |:..:::|:|..:.:..:||::        .:|:.|.
  Fly   625 VCLSLHIHDPYAK--------GWEYSALLFILVNTLSLIFILFSYIRM--------LQAIRDSGG 673

  Rat   770 -----------AMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLN 823
                       .:....|.::..|...:.|:..:..|::.|. .::|:....:.::|||:.:.||
  Fly   674 GMRSTHSGRENVVATRFAIIVTTDCACWLPIIVVKLAALSGC-EISPDLYAWLAVLVLPVNSALN 737

  Rat   824 PLLYLLFNPHFREDLRR 840
            |:||.|....|::.|||
  Fly   738 PVLYTLTTAAFKQQLRR 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr6	XP_573455.1	LRRNT	34..68	CDD:214470	10/36 (28%)
		LRR_RI	<70..248	CDD:238064	60/195 (31%)
		leucine-rich repeat	70..91	CDD:275380	7/21 (33%)
		LRR_8	92..150	CDD:290566	17/72 (24%)
		leucine-rich repeat	92..115	CDD:275380	5/37 (14%)
		leucine-rich repeat	116..139	CDD:275380	7/22 (32%)
		LRR_8	138..198	CDD:290566	19/61 (31%)
		leucine-rich repeat	140..163	CDD:275380	6/22 (27%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		LRR_8	186..246	CDD:290566	23/59 (39%)
		leucine-rich repeat	188..211	CDD:275380	8/22 (36%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..258	CDD:275380	7/21 (33%)
		LRR_RI	253..>442	CDD:238064	44/192 (23%)
		LRR_8	258..314	CDD:290566	9/57 (16%)
		leucine-rich repeat	259..282	CDD:275380	0/22 (0%)
		leucine-rich repeat	283..304	CDD:275380	2/20 (10%)
		LRR_8	305..364	CDD:290566	17/62 (27%)
		leucine-rich repeat	330..344	CDD:275378	0/13 (0%)
		leucine-rich repeat	354..375	CDD:275380	4/20 (20%)
		LRR_8	375..434	CDD:290566	22/58 (38%)
		leucine-rich repeat	376..399	CDD:275380	6/22 (27%)
		leucine-rich repeat	400..421	CDD:275380	9/20 (45%)
		leucine-rich repeat	424..444	CDD:275380	7/19 (37%)
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486	7/24 (29%)
		LRR_RI	<184..397	CDD:238064	80/308 (26%)
		LRR_8	188..248	CDD:290566	20/59 (34%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		leucine-rich repeat	212..235	CDD:275380	6/22 (27%)
		leucine-rich repeat	238..261	CDD:275380	8/22 (36%)
		LRR_8	261..320	CDD:290566	23/58 (40%)
		leucine-rich repeat	262..285	CDD:275380	8/22 (36%)
		LRR_4	284..325	CDD:289563	16/81 (20%)
		leucine-rich repeat	286..309	CDD:275380	8/22 (36%)
		LRR_4	308..348	CDD:289563	18/85 (21%)
		leucine-rich repeat	310..334	CDD:275380	10/69 (14%)
		leucine-rich repeat	335..357	CDD:275380	11/49 (22%)
		LRR_8	356..416	CDD:290566	28/81 (35%)
		leucine-rich repeat	358..381	CDD:275380	10/44 (23%)
		LRR_4	381..421	CDD:289563	17/64 (27%)
		leucine-rich repeat	382..405	CDD:275380	10/22 (45%)
		leucine-rich repeat	406..427	CDD:275380	9/45 (20%)
		7tm_1	483..741	CDD:278431	71/278 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810