DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht4 and Chia1

DIOPT Version :9

Sequence 1:	NP_524962.2	Gene:	Cht4 / 49815	FlyBaseID:	FBgn0022700	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_075675.2	Gene:	Chia1 / 81600	MGIID:	1932052	Length:	473	Species:	Mus musculus

Alignment Length:	492	Identity:	191/492 - (38%)
Similarity:	276/492 - (56%)	Gaps:	52/492 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KLVSIWALAALCLCLGQVASSEKLLNCYWGTWANYRPGDGKFTPSDIDPSLCTHISYTFFGISDA 66
            ||:.:..||  .|...|:.|:..|: ||:..||.||||.|.|.|.||:|.||||:.|.|.|:.:
Mouse     3 KLLLVTGLA--LLLNAQLGSAYNLI-CYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQN- 63

  Fly    67 GEFKSLDTWLDMDDGLGFISQTIALKQRNPNLKILAVVGGWNEGSTKYSAMAADPAKRATFVSTS 131
            .|..::: |.|:.....|..    ||.||..||.|..:||||.|:..::.|.:....|.||:::.
Mouse    64 NEITTIE-WNDVTLYKAFND----LKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSV 123

  Fly   132 LAFIQQYSFDGLDLDWEYPGQRGGSEADRENFVTLLREIKETYDQYGLE-------LGIAVGASE 189
            :.|::||.||||||||||||.||....|:..|..|::|::|.::|..:|       :..||....
Mouse   124 IKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMVTAAVAGGI 188

  Fly   190 KSASISYDIPAISQHLTFINVMTYDFHMALDGYLGLNAPL---PEVAES---------IDYWLSH 242
            .:....|:||.:|::|.||:|||||.|.:.:||.|.|:||   |....|         ::||.::
Mouse   189 SNIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAYLNVDYVMNYWKNN 253

  Fly   243 GAPAEKLILGIGFYGHSYQMSDSSQNWPGAACIGPGTAGVYTRENGFLGYHEIC--LNNWQT-VF 304
            ||||||||:|...|||::.:.:.|.|..||...|.|.||.|||:.||..|:|||  |.:..| |:
Mouse   254 GAPAEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFLRSGATEVW 318

  Fly   305 DQENGAPYAFQGDQWIGYDNPESIQLKMQLVESRNLGGAMMWSIETDDFRG-LCGE-SYPLLKTM 367
            |.....|||::.::|:||||.:|..:|.|.::..|.||||:|:|:.|||.| .|.: .:||..|:
Mouse   319 DASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTL 383

  Fly   368 NRALGREVSGGSGGGGGGGGEGSVTPAPTAAPTSSPTPAPTPGGGSGGNE-----CAQ--DGFFV 425
            |:|||...            ||...|...:.|.::|..:.:.||.|||:.     ||.  ||.:.
Mouse   384 NKALGIST------------EGCTAPDVPSEPVTTPPGSGSGGGSSGGSSGGSGFCADKADGLYP 436

  Fly   426 LESDCNKFYQCVGGVRYDFQCGAGLCFNTITLNCDWP 462
            :..|.|.|:||:.|:.|...|.|||.|:|....|:||
Mouse   437 VADDRNAFWQCINGITYQQHCQAGLVFDTSCNCCNWP 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht4	NP_524962.2	GH18_chitolectin_chitotriosidase	26..371	CDD:119351	150/368 (41%)
		Glyco_18	28..351	CDD:214753	141/344 (41%)
		CBM_14	421..462	CDD:279884	16/40 (40%)
Chia1	NP_075675.2	GH18_chitolectin_chitotriosidase	24..387	CDD:119351	151/369 (41%)
		Glyco_18	24..365	CDD:214753	142/347 (41%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	70..71		0/1 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	97..100		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	210..213		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421		8/26 (31%)
		ChtBD2	426..473	CDD:214696	18/46 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11935
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	339	1.000	Inparanoid score	I2351
Isobase	1	0.950	-	0	Normalized mean entropy	S2365
OMA	1	1.010	-	-		QHG58170
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.930