DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht4 and Cht7

DIOPT Version :9

Sequence 1:	NP_524962.2	Gene:	Cht4 / 49815	FlyBaseID:	FBgn0022700	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_647768.3	Gene:	Cht7 / 38370	FlyBaseID:	FBgn0035398	Length:	1013	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	168/468 - (35%)
Similarity:	246/468 - (52%)	Gaps:	63/468 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 CYWGTWANYRPGDGKFTPSDIDPSLCTHISYTFFGISDAGEFKSLDTWLDMDDGLGFISQTIALK 92
            ||..:|:..|||.|||.|.:|||.|||||.|.|..:.|....::.|     ||...:.| .|||:
  Fly   562 CYLTSWSAKRPGAGKFQPENIDPKLCTHIVYAFATLQDYKLTEATD-----DDPENYES-VIALR 620

  Fly    93 QRNPNLKILAVVGGWNEGSTKYSAMAADPAKRATFVSTSLAFIQQYSFDGLDLDWEYPGQRGGSE 157
            ..||:|:||..:|||..|||.:..:.::..:...||..::.|::.|.|:|||:|||||  ||..
  Fly   621 DNNPDLQILLAIGGWAFGSTPFKELTSNVFRMNQFVYEAIDFLRDYKFNGLDVDWEYP--RGAE- 682

  Fly   158 ADRENFVTLLREIKETYDQYGLELGI-------AVGASEKSASISYDIPAISQHLTFINVMTYDF 215
             ||..:|:||:|::..::......|:       ||.||.::.:..||:|.||::|.|||||||||
  Fly   683 -DRVAYVSLLKELRVAFEGEAKSSGLPRLLLTAAVPASFEAIAAGYDVPEISKYLDFINVMTYDF 746

  Fly   216 HMALDGYLGLNAPLPEVAE--------SIDY----WLSHGAPAEKLILGIGFYGHSYQMSDSSQN 268
            |...:..:|.|:||..:..        ::||    |:..|||.|||::|:..||.|:::.:.:|.
  Fly   747 HGQWERTVGHNSPLFALESATGYQKKLTVDYSAREWVKQGAPKEKLLIGMPTYGRSFELVNDTQF 811

  Fly   269 WPGAACIGPGTAGVYTRENGFLGYHEIC----LNNWQTVFDQENGAPYAFQGDQWIGYDNPESIQ 329
            ..|:...|.|.||.:|.|.|||.|:|:|    .:|...|:|.|...|:|::|:||:|:|:..|::
  Fly   812 DIGSPSSGGGKAGKFTNEAGFLSYYEVCSFLAADNTTLVWDSEQQVPFAYRGNQWVGFDDERSLK 876

  Fly   330 LKMQLVESRNLGGAMMWSIETDDFRGLCGE-SYPLLKTMNRAL-----GREVSGGSGGGGGGGGE 388
            .|.:.::.:..||.|:|||:.|||.|.||. .||||..:|..|     ..|..|.....|..|
  Fly   877 TKTEWLKEQGFGGIMVWSIDMDDFSGRCGSGKYPLLTALNDELKDYKVELEYDGPYESHGPRG-- 939

  Fly   389 GSVTPAPTAAPTSSPTPAPTPGGGSGGNECA-QDGFFVLE---SDCNKFYQCVGGVRYDFQCGAG 449
                    |..|..|...          .|| :||.....   :||..:|.|.|..::...|.|.
  Fly   940 --------AYTTKDPHDV----------TCAEEDGHISYHKDWADCTHYYMCEGERKHHMPCPAN 986

  Fly   450 LCFNTITLNCDWP 462
            |.||.....||||
  Fly   987 LVFNPQENVCDWP 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht4	NP_524962.2	GH18_chitolectin_chitotriosidase	26..371	CDD:119351	142/366 (39%)
		Glyco_18	28..351	CDD:214753	131/345 (38%)
		CBM_14	421..462	CDD:279884	14/43 (33%)
Cht7	NP_647768.3	Glyco_18	124..468	CDD:214753
		GH18_chitolectin_chitotriosidase	125..491	CDD:119351
		Glyco_18	559..898	CDD:214753	131/345 (38%)
		GH18_chitolectin_chitotriosidase	560..919	CDD:119351	142/366 (39%)
		CBM_14	951..1005	CDD:279884	18/49 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463826
Domainoid	1	1.000	188	1.000	Domainoid score	I962
eggNOG	1	0.900	-	-		E1_COG3325
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2365
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	1	1.000	-	-		mtm1002
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
	10	9.800