DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht4 and Cht6

DIOPT Version :9

Sequence 1:	NP_524962.2	Gene:	Cht4 / 49815	FlyBaseID:	FBgn0022700	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_001245598.1	Gene:	Cht6 / 31935	FlyBaseID:	FBgn0263132	Length:	4611	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	189/550 - (34%)
Similarity:	273/550 - (49%)	Gaps:	98/550 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SIWALAALCLCLGQVASSEKLLNCYWGTWANYRPGDGKFTPSDIDPSLCTHISYTFFGISDAGEF 69
            :::.|.||..|:.: ||||..:.||:..|:.||||..||.|.:|:|.||||:.|.|.|.:...:.
  Fly    12 TLFLLCALAYCINE-ASSEGRVVCYYTNWSVYRPGTAKFNPQNINPYLCTHLVYAFGGFTKDNQM 75

  Fly    70 KSLDTWLDMDDGLGFISQTIALKQRNPNLKILAVVGGWNEGSTKYSAMAADPAKRATFVSTSLAF 134
            |..|.:.|::.| |:...| .||..|..||.:..:|||||.|:::|.:.|...:|..|:...|.|
  Fly    76 KPFDKYQDIEQG-GYAKFT-GLKTYNKQLKTMIAIGGWNEASSRFSPLVASNERRQQFIKNILKF 138

  Fly   135 IQQYSFDGLDLDWEYPGQR-GGSEADRENFVTLLREIKETYDQYG-------LELGIAVGASEKS 191
            ::|..|||:|||||||..| ||...||:|:...::|::..:::..       |.|.:||.|..:.
  Fly   139 LRQNHFDGIDLDWEYPAHREGGKSRDRDNYAQFVQELRAEFEREAEKTGRTRLLLTMAVPAGIEY 203

  Fly   192 ASISYDIPAISQHLTFINVMTYDFHMALDGYLGLNAPLPEVAE--------------SIDYWLSH 242
            ....||:|.::::|.:.||:|||||.:.:..:..:|||..:.|              ||.|:|..
  Fly   204 IDKGYDVPKLNKYLDWFNVLTYDFHSSHEPSVNHHAPLYSLEEDSEYNYDAELNIDYSIKYYLKA 268

  Fly   243 GAPAEKLILGIGFYGHSYQMSDSSQNWPGAACIGPGTAGVYTRENGFLGYHEICLN-----NWQT 302
            ||..:||:|||..||.||.:.:......||...|||..|..|||.|:|.|:|||..     .|..
  Fly   269 GADRDKLVLGIPTYGRSYTLINEESTELGAPAEGPGEQGDATREKGYLAYYEICQTLKDDPEWTV 333

  Fly   303 VFDQENG---APYAFQGDQWIGYDNPESIQLKMQLVESRNLGGAMMWSIETDDFRGLC-GESYPL 363
            |  |.|.   .|||::.:||:|||:...::.|.:.|.::.|||.|.|:|:.|||||.| |:.|||
  Fly   334 V--QPNANVMGPYAYRRNQWVGYDDEAIVRKKAEYVVAQGLGGIMFWAIDNDDFRGTCNGKPYPL 396

  Fly   364 L----KTMNRALG---REVSGGSG-------------------GGGGGGGEGSVTPAPTAAPTSS 402
            :    :.|..|||   .||:..||                   .|.......|..|:.|..|..|
  Fly   397 IEAAKEAMVEALGLGINEVAKPSGPQKPSRSRSRDNASNRNRLNGKTEAPLSSRRPSATRRPAVS 461

  Fly   403 PTPAPTPG---------GGS---GGN-----------------ECAQDGFFVLESDCNKFYQC-- 436
            .|.||.|.         |.|   ||.                 :|.::|||....||.|:|.|
  Fly   462 STQAPPPSTTFKLTEAEGSSLYIGGRASTTPPPPTTPDPGSDFKCEEEGFFQHPRDCKKYYWCLD 526

  Fly   437 -----VGGVRYDFQCGAGLCFNTITLNCDW 461
                 :|.|.:.|.|.:||.||....:||:
  Fly   527 SGPSGLGIVAHMFTCPSGLYFNPAADSCDF 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht4	NP_524962.2	GH18_chitolectin_chitotriosidase	26..371	CDD:119351	141/379 (37%)
		Glyco_18	28..351	CDD:214753	130/352 (37%)
		CBM_14	421..462	CDD:279884	18/47 (38%)
Cht6	NP_001245598.1	Glyco_18	31..383	CDD:214753	130/355 (37%)
		GH18_chitolectin_chitotriosidase	32..404	CDD:119351	140/375 (37%)
		CBM_14	506..562	CDD:279884	19/50 (38%)
		Oxidored_q2	<2691..2750	CDD:294335
		CBM_14	4554..4609	CDD:279884
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I962
eggNOG	1	0.900	-	-		E1_COG3325
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	1	1.000	-	-		mtm1002
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.920