DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht4 and Chit1

DIOPT Version :9

Sequence 1:	NP_524962.2	Gene:	Cht4 / 49815	FlyBaseID:	FBgn0022700	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_001073157.1	Gene:	Chit1 / 289032	RGDID:	1305646	Length:	464	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	177/498 - (35%)
Similarity:	259/498 - (52%)	Gaps:	74/498 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LVSIWALAAL-CLCLGQVASSEKLLNCYWGTWANYRPGDGKFTPSDIDPSLCTHISYTFFGISDA 66
            :|...|||.: .|.:.|..|:.||. ||:..||.||.|..:|.|.|:||:||||:.|.|.|:::
  Rat     1 MVQSLALAGVTTLLMIQWGSAAKLF-CYFTNWAQYRSGAARFLPRDVDPNLCTHVIYAFAGLNN- 63

  Fly    67 GEFKSLDTWLDMDDGLGFISQTIALKQRNPNLKILAVVGGWNEGSTKYSAMAADPAKRATFVSTS 131
               ..:.| ::.:|.| |..:..:||:|||.||.|..||||:.|:.|::.|.|..:.|.|||:::
  Rat    64 ---HQVST-VEPNDEL-FYQELNSLKKRNPKLKTLLAVGGWSFGTQKFTDMVATASTRQTFVNSA 123

  Fly   132 LAFIQQYSFDGLDLDWEYPGQRGGSEADRENFVTLLREIKETYDQYG-------LELGIAVGASE 189
            |:|::.:.||||||||||||.||....|:|.|..|::::.:.:.:..       |.|..||....
  Rat   124 LSFLRTHGFDGLDLDWEYPGSRGSPAVDKERFTALIQDLAKAFQEEARASGKSRLLLTAAVPTGR 188

  Fly   190 KSASISYDIPAISQHLTFINVMTYDFHMALDGYLGLNAPL------------PEVAESIDYWLSH 242
            ......|::..|.|.|.|||:|.||||.:.|...|.|:||            ..|..::..||..
  Rat   189 GHVDAGYEVDKIVQSLDFINLMAYDFHSSWDKTTGHNSPLYKRQGETGKDAEKNVDAAVTLWLQK 253

  Fly   243 GAPAEKLILGIGFYGHSYQMSDSSQNWPGAACIGPGTAGVYTRENGFLGYHEICLNNW---QTVF 304
            |.||.||:||:..||.|:.::.||.:..||...|||..|.||:|.|.|.|.|:|  :|   |.:.
  Rat   254 GTPASKLMLGMPAYGRSFTLASSSDSGVGAPATGPGAPGPYTKEKGILVYFEVC--SWKGKQRIE 316

  Fly   305 DQENGAPYAFQGDQWIGYDNPESIQLKMQLVESRNLGGAMMWSIETDDFRG-LCGE-SYPLLKTM 367
            ||:  .||..||:||:|:|:.||.:.|...|:.:.|||||:|.::.|||:| .|.| .|||::|:
  Rat   317 DQK--VPYVSQGNQWVGFDDRESFRAKAAYVKQKGLGGAMVWILDGDDFKGSFCNEGQYPLIRTL 379

  Fly   368 NRALGREVSGGSGGGGGGGGEGSVTPAPTAAP---------TSSPTPAPTPG-----GGSGGNEC 418
            ::.|                  |::..|..:|         .|.|...|:||     .|..
  Rat   380 HQEL------------------SLSSGPPRSPEQEVPGPHQPSEPEQGPSPGLDDFCQGKA---- 422

  Fly   419 AQDGFFVLESDCNKFYQCVGGVRYDFQCGAGLCFNTITLNCDW 461
              ||.:...::.:.||.|.||..:...|..||.|......|.|
  Rat   423 --DGLYPNPTEKSSFYSCGGGRLFQHSCPPGLVFIDSCKCCTW 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht4	NP_524962.2	GH18_chitolectin_chitotriosidase	26..371	CDD:119351	145/368 (39%)
		Glyco_18	28..351	CDD:214753	135/344 (39%)
		CBM_14	421..462	CDD:279884	13/41 (32%)
Chit1	NP_001073157.1	GH18_chitolectin_chitotriosidase	24..383	CDD:119351	146/369 (40%)
Chit1	NP_001073157.1	ChtBD2	416..463	CDD:214696	13/52 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350387
Domainoid	1	1.000	45	1.000	Domainoid score	I11889
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2302
OMA	1	1.010	-	-		QHG58170
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.910