DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht4 and CHIA

DIOPT Version :9

Sequence 1:	NP_524962.2	Gene:	Cht4 / 49815	FlyBaseID:	FBgn0022700	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_970615.2	Gene:	CHIA / 27159	HGNCID:	17432	Length:	476	Species:	Homo sapiens

Alignment Length:	494	Identity:	184/494 - (37%)
Similarity:	264/494 - (53%)	Gaps:	66/494 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LAALCLCLGQVASSEKLLNCYWGTWANYRPGDGKFTPSDIDPSLCTHISYTFFGISDAGEFKSLD 73
            |..|.|.|.....|...|.||:..||.||||.|:|.|.:|||.||||:.|.|.|..: .|..:::
Human     7 LTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQN-NEITTIE 70

  Fly    74 TWLDMDDGLGFISQTI-ALKQRNPNLKILAVVGGWNEGSTKYSAMAADPAKRATFVSTSLAFIQQ 137
             |.|:.     :.|.. .||.:|..||.|..:||||.|:..::||.:.|..|.||:::.:.|::|
Human    71 -WNDVT-----LYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQ 129

  Fly   138 YSFDGLDLDWEYPGQRGGSEADRENFVTLLREIKETYDQYGLELG-------IAVGASEKSASIS 195
            |.|||||.||||||.||....|:..|..|::|::|.::|...::.       .||.|...:....
Human   130 YEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSG 194

  Fly   196 YDIPAISQHLTFINVMTYDFHMALDGYLGLNAPLPE------------VAESIDYWLSHGAPAEK 248
            |:||.:||:|.:|:|||||.|.:.:||.|.|:||.:            |...::||..:||||||
Human   195 YEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEK 259

  Fly   249 LILGIGFYGHSYQMSDSSQNWPGAACIGPGTAGVYTRENGFLGYHEIC--LNNWQTV-FDQENGA 310
            ||:|...|||::.:|:.|....||...|.|.||.|.:|:|...|:|||  |.|..|. :|.....
Human   260 LIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEV 324

  Fly   311 PYAFQGDQWIGYDNPESIQLKMQLVESRNLGGAMMWSIETDDFRG-LCGE-SYPLLKTMNRALGR 373
            |||:||:.|:||||.:|..:|.|.::....||||:|:|:.|||.| .|.: .:||:.|:.:|||.
Human   325 PYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGL 389

  Fly   374 E-------------VSGGSGGGGGGGGEGSVTPAPTAAPTSSPTPAPTPGGGSGGNE-CA--QDG 422
            :             ::....|.|.|.|..|                  .||.|||:. ||  .:|
Human   390 QSASCTAPAQPIEPITAAPSGSGNGSGSSS------------------SGGSSGGSGFCAVRANG 436

  Fly   423 FFVLESDCNKFYQCVGGVRYDFQCGAGLCFNTITLNCDW 461
            .:.:.::.|.|:.||.||.|...|.|||.|:|....|:|
Human   437 LYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNW 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht4	NP_524962.2	GH18_chitolectin_chitotriosidase	26..371	CDD:119351	148/369 (40%)
		Glyco_18	28..351	CDD:214753	139/345 (40%)
		CBM_14	421..462	CDD:279884	16/41 (39%)
CHIA	NP_970615.2	GH18_chitolectin_chitotriosidase	24..387	CDD:119351	148/369 (40%)
		Glyco_18	26..365	CDD:214753	139/345 (40%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	70..71		0/1 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	97..100		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	210..213		2/2 (100%)
		ChtBD2	429..476	CDD:214696	18/47 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2501
Isobase	1	0.950	-	0	Normalized mean entropy	S2365
OMA	1	1.010	-	-		QHG58170
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.930