DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht4 and CTBS

DIOPT Version :9

Sequence 1:	NP_524962.2	Gene:	Cht4 / 49815	FlyBaseID:	FBgn0022700	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_004379.1	Gene:	CTBS / 1486	HGNCID:	2496	Length:	385	Species:	Homo sapiens

Alignment Length:	415	Identity:	89/415 - (21%)
Similarity:	146/415 - (35%)	Gaps:	133/415 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLVSIWALAALCLCLGQVASSEKLLNCYWGTWANYRPGDGKFTPSDIDPSLCT----HISYTFF 61
            :.|:::.||.||.|..|        .:|                |.. :|.||.    |..:..|
Human    22 LALLALLALLALRLAAG--------TDC----------------PCP-EPELCRPIRHHPDFEVF 61

  Fly    62 GISDAGEFKSLDTWLDMDDGLGFISQTIALKQRNPNLKILAVVGGWNEGST-----KYSAM---- 117
             :.|.|:    .||...|                           |::.:|     ||.:.
Human    62 -VFDVGQ----KTWKSYD---------------------------WSQITTVATFGKYDSELMCY 94

  Fly   118 ------------------AADPAKRATFVSTSLAFIQQYSFDGLDLDWEYPGQRGGSEADRENFV 164
                              ..|||.||::::..|...:....||:::|.|........|.|
Human    95 AHSKGARVVLKGDVSLKDIIDPAFRASWIAQKLNLAKTQYMDGINIDIEQEVNCLSPEYD----- 154

  Fly   165 TLLREIKETYDQY-----GLELGIAVGASEKSAS-ISYDIPAISQHLTFINVMTYDFHMAL--DG 221
            .|...:|||.|.:     |.::...|..|.|:.. ..|:...|:....|:.||:||....:  :.
Human   155 ALTALVKETTDSFHREIEGSQVTFDVAWSPKNIDRRCYNYTGIADACDFLFVMSYDEQSQIWSEC 219

  Fly   222 YLGLNAPLPEVAESIDYWLSHGAPAEKLILGIGFYGHSYQMSDSSQN---------WPGAACIGP 277
            ....|||..:.....:.::......:||::|:.:||:.|...:.|::         :.||.|  .
Human   220 IAAANAPYNQTLTGYNDYIKMSINPKKLVMGVPWYGYDYTCLNLSEDHVCTIAKVPFRGAPC--S 282

  Fly   278 GTAG-------VYTRENGFLGYHEICLNNWQTVFDQENGAPYAFQGD-----QWIGYDNPESIQL 330
            ..||       :..:.|.     .|..|.|    |::..|||....|     ..:.||||:||.|
Human   283 DAAGRQVPYKTIMKQINS-----SISGNLW----DKDQRAPYYNYKDPAGHFHQVWYDNPQSISL 338

  Fly   331 KMQLVESRNLGGAMMWSIETDDFRG 355
            |...:::..|.|..||:....|:.|
Human   339 KATYIQNYRLRGIGMWNANCLDYSG 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht4	NP_524962.2	GH18_chitolectin_chitotriosidase	26..371	CDD:119351	82/390 (21%)
		Glyco_18	28..351	CDD:214753	80/382 (21%)
		CBM_14	421..462	CDD:279884
CTBS	NP_004379.1	GH18_chitobiase	39..378	CDD:119354	82/390 (21%)
CTBS	NP_004379.1	Glyco_18	<115..358	CDD:214753	64/258 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D826687at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820