back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht4 and CHI3L1

DIOPT Version :9

Sequence 1:	NP_524962.2	Gene:	Cht4 / 49815	FlyBaseID:	FBgn0022700	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_001267.2	Gene:	CHI3L1 / 1116	HGNCID:	1932	Length:	383	Species:	Homo sapiens

Alignment Length:	390	Identity:	159/390 - (40%)
Similarity:	226/390 - (57%)	Gaps:	54/390 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LCLGQVASSEKLLNCYWGTWANYRPGDGKFTPSDIDPSLCTHISYTFFGISDAGEFKSLDTWLDM 78
            |.|.|..|:.||: ||:.:|:.||.|||...|..:|..|||||.|:|..||:    ..:|||...
Human    13 LVLLQCCSAYKLV-CYYTSWSQYREGDGSCFPDALDRFLCTHIIYSFANISN----DHIDTWEWN 72

  Fly    79 DDGL-GFISQTIALKQRNPNLKILAVVGGWNEGSTKYSAMAADPAKRATFVSTSLAFIQQYSFDG 142
            |..| |.::   .||.||||||.|..|||||.||.::|.:|::...|.||:.:...|::.:.|||
Human    73 DVTLYGMLN---TLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTFIKSVPPFLRTHGFDG 134

  Fly   143 LDLDWEYPGQRGGSEADRENFVTLLREIKETY---DQYG---LELGIAVGASEKSASISYDIPAI 201
            |||.|.|||:|     |:::|.||::|:|..:   .|.|   |.|..|:.|.:.:...||||..|
Human   135 LDLAWLYPGRR-----DKQHFTTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKI 194

  Fly   202 SQHLTFINVMTYDFHMALDGYLGLNAPL--------PEVAESIDYWLSH----GAPAEKLILGIG 254
            ||||.||::||||||.|..|..|.::||        |:...:.||.:.:    ||||.||::||.
Human   195 SQHLDFISIMTYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIP 259

  Fly   255 FYGHSYQMSDSSQNWPGAACIGPGTAGVYTRENGFLGYHEICLNNWQTVFDQENGA--------- 310
            .:|.|:.:: ||:...||...|||..|.:|:|.|.|.|:|||        |...||
Human   260 TFGRSFTLA-SSETGVGAPISGPGIPGRFTKEAGTLAYYEIC--------DFLRGATVHRILGQQ 315

  Fly   311 -PYAFQGDQWIGYDNPESIQLKMQLVESRNLGGAMMWSIETDDFRG-LCGES--YPLLKTMNRAL 371
             |||.:|:||:|||:.||::.|:|.::.|.|.|||:|:::.|||:| .||:.  :||...:..||
Human   316 VPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQDLRFPLTNAIKDAL 380

Fly 372 371
Human 381 380

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.