Protein Alignment eIF4H1 and NAM8

DIOPT Version :10

• Sequence 1: NP_001285330.1
• Gene: eIF4H1 / 49809
• FlyBaseID: FBgn0262734
• Length: 388
• Species: Drosophila melanogaster
• Sequence 2: NP_011954.1
• Gene: NAM8 / 856486
• SGDID: S000001128
• Length: 523
• Species: Saccharomyces cerevisiae
• Alignment Length: 296
• Identity: 52/296 - (17%)
• Similarity: 83/296 - (28%)
• Gaps: 131/296 - (44%)

  Fly    32 FVGNLPQGLVQGDVIKIF--QDFEVKYVRLVKDRETDQFKGFCYVEFETLDNLERALE------C 88
            |||:|...:.:..:.::|  :.....:.::|.|:.|...||:.:|:|...|..:.||.      .
Yeast   166 FVGDLAPNVTESQLFELFINRYASTSHAKIVHDQVTGMSKGYGFVKFTNSDEQQLALSEMQGVFL 230

  Fly    89 DGR-IKLDDLSAPLRIDIADRRKNDRPGGGVGGGNGGMTRGDGGRDGFQKRGPPRQGGSSQSYSR 152
            :|| ||:
Yeast   231 NGRAIKV---------------------------------------------------------- 237

  Fly   153 GGPGTGGGGREGGGGSGNRGDSRGSYIDSYGGHNDRSRGVG-GSGAGSGGGMNRGYNDRPANRGR 216
             ||.:|......|....||..|      |....|..||.:. |....|.|..|.|
Yeast   238 -GPTSGQQQHVSGNNDYNRSSS------SLNNENVDSRFLSKGQSFLSNGNNNMG---------- 285

  Fly   217 YGSFNNDDRPFERNQDRDRGQREGSYGNQSRDGDRYNNFNRHRDRERTHYNPNQQSERPSGGMTG 281
                      |:||.     ..:..|..|.:..  .|:|.          :||..:
Yeast   286 ----------FKRNH-----MSQFIYPVQQQPS--LNHFT----------DPNNTT--------- 314

  Fly   282 LGGGSGGSGGLGVGGGSSMGAIDNFRHFKKPISRII 317
                      :.:||.||:...|..|.:.:|...|:
Yeast   315 ----------VFIGGLSSLVTEDELRAYFQPFGTIV 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4H1	NP_001285330.1	RRM_eIF4H	24..110	CDD:409835	19/86 (22%)
NAM8	NP_011954.1	RRM1_NGR1_NAM8_like	55..144	CDD:410023
		RRM2_SECp43_like	162..241	CDD:409781	21/133 (16%)
		RRM3_NGR1_NAM8_like	312..383	CDD:409782	8/48 (17%)