Protein Alignment eIF4H1 and Eif4b

DIOPT Version :10

• Sequence 1: NP_001285330.1
• Gene: eIF4H1 / 49809
• FlyBaseID: FBgn0262734
• Length: 388
• Species: Drosophila melanogaster
• Sequence 2: NP_663600.2
• Gene: Eif4b / 75705
• MGIID: 95304
• Length: 611
• Species: Mus musculus
• Alignment Length: 402
• Identity: 106/402 - (26%)
• Similarity: 155/402 - (38%)
• Gaps: 126/402 - (31%)

  Fly    17 DRASKQLPTEPPFIAFVGNLPQGLVQGDVIKIFQDFEVKYVRLVKD-RETDQFKGFCYVEFETLD 80
            ||:  :||..||:.||:||||..:.:..:...|:...:..|||.:: ...|:.|||.|.|||.||
Mouse    86 DRS--RLPKSPPYTAFLGNLPYDVTEDSIKDFFRGLNISAVRLPREPSNPDRLKGFGYAEFEDLD 148

  Fly    81 NLERALECDGRIKLDDL-SAPLRIDIADRRKN-DRPGGGVGGGNGGMTRGDGGRDGFQKRGPPRQ 143
            :|..||.    :..:.| :..:|:|:||:.:: ||.....|        .|..||..:.....|.
Mouse   149 SLLSALS----LNEESLGNRRIRVDVADQAQDKDRDDRSFG--------RDRNRDSDKTDTDWRA 201

  Fly   144 GGSSQSYSRGGPGTGGGGREGGGGSGNRGDSRGSYIDSYGGHNDRSRGVGGSGAGSGGGMNRGYN 208
            ..::.|:....|      |.|....|::      |.|.|  .:||.|          .|...||.
Mouse   202 RPTTDSFDDYPP------RRGDDSFGDK------YRDRY--DSDRYR----------DGYRDGYR 242

  Fly   209 DRP-ANRGRYGSFNNDDRPFERNQDRDRGQREGS----YGNQSR-------DGDRY-NNFNRHRD 260
            |.| .:..|||..:..|....|:.||....|.||    :|:..|       .|||| :.::|..|
Mouse   243 DGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDD 307

  Fly   261 R---ERTHYNPNQQSERPSGGMTGLGGGSGGSGGLGVGGGSSMGAIDNFRHFKKPISRIISNMCQ 322
            |   .|..|:.                                   |::|...:
Mouse   308 RSWSSRDDYSR-----------------------------------DDYRRDDR----------- 326

  Fly   323 SRVSQLAVPRTNDNERPRLQLKPRTIAAPINAVAETKQS---ASIFGNAKP---------REEKL 375
                       ...:||||.||||:.....:|.|.|.||   |||||.|||         .||:|
Mouse   327 -----------GPPQRPRLNLKPRSAPKEDDASASTSQSSRAASIFGGAKPVDTAAREREVEERL 380

  Fly   376 KELQQNVNHNGD 387
            ::.|:.:....|
Mouse   381 QKEQEKLQRQLD 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4H1	NP_001285330.1	RRM_eIF4H	24..110	CDD:409835	31/87 (36%)
Eif4b	NP_663600.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..93		4/8 (50%)
		RRM_eIF4B	94..175	CDD:409836	30/84 (36%)
		PRK12678	<158..>273	CDD:237171	35/146 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..611		72/309 (23%)
		PTZ00108	<372..578	CDD:240271	5/21 (24%)