DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4H1 and EIF4H

DIOPT Version :9

Sequence 1:	NP_001285330.1	Gene:	eIF4H1 / 49809	FlyBaseID:	FBgn0262734	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_071496.1	Gene:	EIF4H / 7458	HGNCID:	12741	Length:	248	Species:	Homo sapiens

Alignment Length:	380	Identity:	121/380 - (31%)
Similarity:	165/380 - (43%)	Gaps:	151/380 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GRGGYEHARSGFGGDRASKQLPTEPPFIAFVGNLPQGLVQGDVIKIFQDFEVKYVRLVKDRETDQ 67
            |||  ....:|..|.|:.|:||||||:.|:|||||...||||:..||:|..::.||||:|::||:
Human    18 GRG--SRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDK 80

  Fly    68 FKGFCYVEFETLDNLERALECDGRIKLDDLSAPLRIDIADRRKNDRPGGGVGGGNGGMTRGDGGR 132
            |||||||||:.:|:|:.||..||.: |.|.|  ||:|||:.||.|:         ||.
Human    81 FKGFCYVEFDEVDSLKEALTYDGAL-LGDRS--LRVDIAEGRKQDK---------GGF------- 126

  Fly   133 DGFQKRGPPRQG-GSSQSYSRGGPGTGGGGREGGGGSGNRGDSRGSYIDSYGGHNDRSRGVGGSG 196
             ||:|.||..:| |||              ||..||..:|.|....:.|.:.|      |.|||
Human   127 -GFRKGGPDDRGMGSS--------------RESRGGWDSRDDFNSGFRDDFLG------GRGGS- 169

  Fly   197 AGSGGGMNRGYNDRPANRGRYGSFNNDDRPFERNQDRDRGQREG-SYGNQSRDGDRYNNFNRHRD 260
                         ||.:|                       |.| ..|::.|||....
Human   170 -------------RPGDR-----------------------RTGPPMGSRFRDGPPLR------- 191

  Fly   261 RERTHYNPNQQSERPSGGMTGLGGGSGGSGGLGVGGGSSMGAIDNFRHFKKPISRIISNMCQSRV 325
                                                ||:|       .|::|..       :.|.
Human   192 ------------------------------------GSNM-------DFREPTE-------EERA 206

  Fly   326 SQLAVPRTNDNERPRLQLKPRTIAAPINAVAETKQSASIFGNAKPREEKLKELQQ 380
                       :||||||||||:|.|:|.||  ..:::|||.|:||||.:::.|:
Human   207 -----------QRPRLQLKPRTVATPLNQVA--NPNSAIFGGARPREEVVQKEQE 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4H1	NP_001285330.1	RRM	<19..>139	CDD:223796	58/119 (49%)
eIF4H1	NP_001285330.1	RRM_eIF4H	28..106	CDD:240847	42/77 (55%)
EIF4H	NP_071496.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		11/24 (46%)
		RRM_eIF4H	37..120	CDD:409835	48/85 (56%)
		SF-CC1	<40..>227	CDD:273721	101/333 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..248		62/270 (23%)
		HHV-1 Vhs binding site	137..157		10/33 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140670
Domainoid	1	1.000	83	1.000	Domainoid score	I8353
eggNOG	1	0.900	-	-		E33208_3BCZ7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	183	1.000	Inparanoid score	I3975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1530583at2759
OrthoFinder	1	1.000	-	-		FOG0006177
OrthoInspector	1	1.000	-	-		otm41666
orthoMCL	1	0.900	-	-		OOG6_107509
Panther	1	1.100	-	-	LDO	PTHR23236
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1292
SonicParanoid	1	1.000	-	-		X4457
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790