DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4H1 and eif4h

DIOPT Version :9

Sequence 1:	NP_001285330.1	Gene:	eIF4H1 / 49809	FlyBaseID:	FBgn0262734	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001184257.1	Gene:	eif4h / 402996	ZFINID:	ZDB-GENE-010328-19	Length:	262	Species:	Danio rerio

Alignment Length:	373	Identity:	133/373 - (35%)
Similarity:	165/373 - (44%)	Gaps:	133/373 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GGYEHARSGFG--GDRASKQLPTEPPFIAFVGNLPQGLVQGDVIKIFQDFEVKYVRLVKDRETDQ 67
            ||....|.|.|  |.|..|:||||||:.|:|||||...||||:..||:|..|:.||||:|:|||:
Zfish    18 GGGRGPRGGGGPSGPRKQKELPTEPPYTAYVGNLPFNTVQGDIDAIFRDLSVRSVRLVRDKETDK 82

  Fly    68 FKGFCYVEFETLDNLERALECDGRIKLDDLSAPLRIDIADRRKNDRPGGGVGGGNGGMTRGDGGR 132
            |||||||||:.|::|:.||..||.: |.|.|  ||:|||:.|:.:|     |||..|..:.|.||
Zfish    83 FKGFCYVEFDDLESLKEALTYDGAL-LGDRS--LRVDIAEGRRQER-----GGGGFGFRKDDRGR 139

  Fly   133 DGFQKRGPPRQGGSSQSYSRGGPGTGGGGREGGGGSGNRGDSRGSYIDSYGGHNDRSRGVGGSGA 197
                       |||.        |..||||          |||..:        |:|   ||..|
Zfish   140 -----------GGSR--------GARGGGR----------DSREDF--------DQS---GGGAA 164

  Fly   198 GSGGGMNRGYNDRPANRGRYGSFNNDDRPFERNQDRDRGQREGSYGNQSRDGDRYNNFNRHRDRE 262
            |..|                  |.:||                ..|.:||.|.
Zfish   165 GEMG------------------FRDDD----------------FMGGRSRGGG------------ 183

  Fly   263 RTHYNPNQQSERPSGGMTGLGGGSGGSGGLG-VGGGSSMGAIDNFRHFKKPISRIISNMCQSRVS 326
                       ||.....|.|||.||.||:| ...|...|...:||.
Zfish   184 -----------RPGDRRGGAGGGGGGGGGMGRFRDGPPRGGQTDFRE------------------ 219

  Fly   327 QLAVPRTNDN-ERPRLQLKPRTIAAPINAVAETKQSASIFGNAKPREE 373
                |...:. :||||||||||:|.|:|.||  ..:::|||.||||||
Zfish   220 ----PSDEERAQRPRLQLKPRTVAGPLNQVA--NPNSAIFGGAKPREE 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4H1	NP_001285330.1	RRM	<19..>139	CDD:223796	61/119 (51%)
eIF4H1	NP_001285330.1	RRM_eIF4H	28..106	CDD:240847	44/77 (57%)
eif4h	NP_001184257.1	RRM	<39..>118	CDD:223796	48/81 (59%)
eif4h	NP_001184257.1	RRM_eIF4H	43..118	CDD:240847	44/77 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573382
Domainoid	1	1.000	80	1.000	Domainoid score	I8534
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4292
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1530583at2759
OrthoFinder	1	1.000	-	-		FOG0006177
OrthoInspector	1	1.000	-	-		otm24970
orthoMCL	1	0.900	-	-		OOG6_107509
Panther	1	1.100	-	-	LDO	PTHR23236
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4457
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900