DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4H1 and Eif4h

DIOPT Version :9

Sequence 1:	NP_001285330.1	Gene:	eIF4H1 / 49809	FlyBaseID:	FBgn0262734	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_291039.1	Gene:	Eif4h / 22384	MGIID:	1341822	Length:	248	Species:	Mus musculus

Alignment Length:	379	Identity:	121/379 - (31%)
Similarity:	164/379 - (43%)	Gaps:	149/379 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GRGGYEHARSGFGGDRASKQLPTEPPFIAFVGNLPQGLVQGDVIKIFQDFEVKYVRLVKDRETDQ 67
            |||  ....:|..|.|:.|:||||||:.|:|||||...||||:..||:|..::.||||:|::||:
Mouse    18 GRG--SRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDK 80

  Fly    68 FKGFCYVEFETLDNLERALECDGRIKLDDLSAPLRIDIADRRKNDRPGGGVGGGNGGMTRGDGGR 132
            |||||||||:.:|:|:.||..||.: |.|.|  ||:|||:.||.|:         ||.
Mouse    81 FKGFCYVEFDEVDSLKEALTYDGAL-LGDRS--LRVDIAEGRKQDK---------GGF------- 126

  Fly   133 DGFQKRGPPRQGGSSQSYSRGGPGTGGGGREGGGGSGNRGDSRGSYIDSYGGHNDRSRGVGGSGA 197
             ||:|.||..:|             .||.||..||..:|.|....|.|.:.|      |.|||
Mouse   127 -GFRKGGPDDRG-------------MGGSRESRGGWDSRDDFNSGYRDDFLG------GRGGS-- 169

  Fly   198 GSGGGMNRGYNDRPANRGRYGSFNNDDRPFERNQDRDRGQREG-SYGNQSRDGDRYNNFNRHRDR 261
                        ||.:|                       |.| ..|::.|||....
Mouse   170 ------------RPGDR-----------------------RAGPPMGSRFRDGPPLR-------- 191

  Fly   262 ERTHYNPNQQSERPSGGMTGLGGGSGGSGGLGVGGGSSMGAIDNFRHFKKPISRIISNMCQSRVS 326
                                               ||:|       .|::|..       :.|.
Mouse   192 -----------------------------------GSNM-------DFREPTE-------EERA- 206

  Fly   327 QLAVPRTNDNERPRLQLKPRTIAAPINAVAETKQSASIFGNAKPREEKLKELQQ 380
                      :||||||||||:|.|:|.||  ..:::|||.|:||||.:::.|:
Mouse   207 ----------QRPRLQLKPRTVATPLNQVA--NPNSAIFGGARPREEVVQKEQE 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4H1	NP_001285330.1	RRM	<19..>139	CDD:223796	58/119 (49%)
eIF4H1	NP_001285330.1	RRM_eIF4H	28..106	CDD:240847	42/77 (55%)
Eif4h	NP_291039.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		11/24 (46%)
		RRM_eIF4H	37..120	CDD:409835	48/85 (56%)
		SF-CC1	<40..>227	CDD:273721	101/332 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..248		62/268 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830641
Domainoid	1	1.000	85	1.000	Domainoid score	I8179
eggNOG	1	0.900	-	-		E33208_3BCZ7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	187	1.000	Inparanoid score	I3902
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006177
OrthoInspector	1	1.000	-	-		otm43712
orthoMCL	1	0.900	-	-		OOG6_107509
Panther	1	1.100	-	-	LDO	PTHR23236
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1292
SonicParanoid	1	1.000	-	-		X4457
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.780