DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4H1 and EIF4B

DIOPT Version :9

Sequence 1:	NP_001285330.1	Gene:	eIF4H1 / 49809	FlyBaseID:	FBgn0262734	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001287750.1	Gene:	EIF4B / 1975	HGNCID:	3285	Length:	616	Species:	Homo sapiens

Alignment Length:	409	Identity:	105/409 - (25%)
Similarity:	154/409 - (37%)	Gaps:	140/409 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DRASKQLPTEPPFIAFVGNLPQGLVQGDVIKIFQDFEVKYVRLVKD-RETDQFKGFCYVEFETLD 80
            ||:  :||..||:.||:||||..:.:..:.:.|:...:..|||.:: ...::.|||.|.|||.||
Human    86 DRS--RLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLD 148

  Fly    81 NLERALECDGRIKLDDL-SAPLRIDIA----DRRKNDRPGGGVGGGNGGMT----RGDGGRDGFQ 136
            :|..||.    :..:.| :..:|:|:|    |:.::||..|.....:...|    |.....|.|.
Human   149 SLLSALS----LNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFD 209

  Fly   137 KRGPPRQGGSSQSYSRGGPGTGGGGREGGGGSGNRGDSRGSYIDSYGGHNDRSRGVGGSGAGSGG 201
            .. |||:|..|                       .||   .|.|.|  .:||.|          .
Human   210 DY-PPRRGDDS-----------------------FGD---KYRDRY--DSDRYR----------D 235

  Fly   202 GMNRGYNDRP-ANRGRYGSFNNDDRPFERNQDRDRGQREGS----YGNQSR-------DGDRY-N 253
            |...||.|.| .:..|||..:..|....|:.||....|.||    :|:..|       .|||| :
Human   236 GYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYED 300

  Fly   254 NFNRHRDR---ERTHYNPNQQSERPSGGMTGLGGGSGGSGGLGVGGGSSMGAIDNFRHFKKPISR 315
            .::|..||   .|..|:.                                   |::|...:
Human   301 RYDRRDDRSWSSRDDYSR-----------------------------------DDYRRDDR---- 326

  Fly   316 IISNMCQSRVSQLAVPRTNDNERPRLQLKPRTIAAPINAVAETKQS---ASIFGNAKP------- 370
                              ...:||:|.||||:.....::.|.|.||   |||||.|||
Human   327 ------------------GPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAARE 373

  Fly   371 --REEKLKELQQNVNHNGD 387
              .||:|::.|:.:....|
Human   374 REVEERLQKEQEKLQRQLD 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4H1	NP_001285330.1	RRM	<19..>139	CDD:223796	38/129 (29%)
eIF4H1	NP_001285330.1	RRM_eIF4H	28..106	CDD:240847	26/79 (33%)
EIF4B	NP_001287750.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..93		4/8 (50%)
		RRM	<83..>190	CDD:223796	36/109 (33%)
		RRM_eIF4B	95..171	CDD:240848	26/79 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1530583at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1292
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950