DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Dd and SERPINE3

DIOPT Version :9

Sequence 1:	NP_001163067.1	Gene:	Spn42Dd / 49808	FlyBaseID:	FBgn0028988	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001094790.1	Gene:	SERPINE3 / 647174	HGNCID:	24774	Length:	424	Species:	Homo sapiens

Alignment Length:	398	Identity:	112/398 - (28%)
Similarity:	181/398 - (45%)	Gaps:	69/398 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VTSVACQTSKEIYQLLSKSHTNQNLVVSPVSIETILSMVFMGAEGSTAKELQSALGLPSED---K 71
            :|.:..:.:..:||.::......|.|:||..:...|.::..||||||.::|..|||....|   |
Human    26 MTLLKTEFALHLYQSVAACRNETNFVISPAGVSLPLEILQFGAEGSTGQQLADALGYTVHDKRVK 90

  Fly    72 EAVAARYGALLNDLQGQEEGPILKLANRIYVNDQYSLNQNY--------NLAVREPFKSEAESIS 128
            :.:.|.|..|....||.|    ::||..::|.....|:..:        |.::.....||..|.:
Human    91 DFLHAVYATLPTSSQGTE----MELACSLFVQVGTPLSPCFVEHVSWWANSSLEPADLSEPNSTA 151

  Fly   129 L---------TNGPVAAERINQWVLDQTSGKIKGMIDPGSMTSDVKALLVNAIYFKGQWESKFDP 184
            :         |.|...:|....|..:|.|.....::            ||:.:.|:|.|..:|..
Human   152 IQTSEGASRETAGGGPSEGPGGWPWEQVSAAFAQLV------------LVSTMSFQGTWRKRFSS 204

  Fly   185 AKTRASTFQVTANKSVPVQMMAQMGTFRANY--FRDL---DAQVIELPYLNSNLSMTIFLPREVE 244
            ..|:...|.......:.|.||.|  |...||  |:|.   ...|:|||||.|.:|:.:.|||:.:
Human   205 TDTQILPFTCAYGLVLQVPMMHQ--TTEVNYGQFQDTAGHQVGVLELPYLGSAVSLFLVLPRDKD 267

  Fly   245 -GLSALEEKIVGFARPLVAKEVYL------------KLPKFKIEFRDELKETLEKLGIRELFTD- 295
             .||.:|..       |.|..::|            .||:|:|:.:..||..|...|:.:||..
Human   268 TPLSHIEPH-------LTASTIHLWTTSLRRARMDVFLPRFRIQNQFNLKSILNSWGVTDLFDPL 325

  Fly   296 KSDLSGLFADKSGGKVSQVSHKAFLEVNEEGAEAAGATSVAVTNRAGFSTFLMADHPFAFVIRDA 360
            |::|.|: :.:.|..||:..|||.:||.|||.:|:|||::.:..|:....| .||.||.:.:|:.
Human   326 KANLKGI-SGQDGFYVSEAIHKAKIEVLEEGTKASGATALLLLKRSRIPIF-KADRPFIYFLREP 388

  Fly   361 N---TIYF 365
            |   |::|
Human   389 NTGITVFF 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Dd	NP_001163067.1	SERPIN	16..369	CDD:238101	111/392 (28%)
SERPINE3	NP_001094790.1	SERPIN	31..399	CDD:238101	111/393 (28%)
SERPINE3	NP_001094790.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..174		6/30 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020