DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Dd and SERPINA5

DIOPT Version :9

Sequence 1:	NP_001163067.1	Gene:	Spn42Dd / 49808	FlyBaseID:	FBgn0028988	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_000615.3	Gene:	SERPINA5 / 5104	HGNCID:	8723	Length:	406	Species:	Homo sapiens

Alignment Length:	364	Identity:	116/364 - (31%)
Similarity:	193/364 - (53%)	Gaps:	19/364 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EIYQLLSKSHTNQNLVVSPVSIETILSMVFMGAEGSTAKELQSALGL---PSEDKEAVAARYGAL 81
            ::|:.|:.:..:|::..|||||...|:|:.:||..||..::...|||   .|.:|| :...:..|
Human    51 DLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE-LHRGFQQL 114

  Fly    82 LNDLQGQEEGPILKLANRIYVNDQYSLNQNYNLAVREPFKSEAESISLTNGPVAAERINQWVLDQ 146
            |.:|....:|..|.|.|.::.:....|...:..|::..:.::....:..:...|.::||.:|..|
Human   115 LQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQ 179

  Fly   147 TSGKIKGMIDPGSMTSDVKALLVNAIYFKGQWESKFDPAKTRASTFQVTANKSVPVQMMAQMGTF 211
            |.|||..::.  ::.|:...::||.|:||.:||:.|:...|:...|.||:...|.|.||::...:
Human   180 TKGKIVDLLK--NLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQY 242

  Fly   212 RANYFRDLDAQVIELPYLNSNLSMTIFLPRE-----VE-GLSALEEKIVGFARPLVAKEVYLKLP 270
            .....|:|..:|:.:|| ..|.:....||.|     || |||  |:.:..:.:....:::.|.||
Human   243 HYLLDRNLSCRVVGVPY-QGNATALFILPSEGKMQQVENGLS--EKTLRKWLKMFKKRQLELYLP 304

  Fly   271 KFKIEFRDELKETLEKLGIRELFTDKSDLSGLFADKSGGKVSQVSHKAFLEVNEEGAEAAGATSV 335
            ||.||...:|::.|..|||..:||..:||||: ::.|..:||::.|||.:||:|.|..||.||..
Human   305 KFSIEGSYQLEKVLPSLGISNVFTSHADLSGI-SNHSNIQVSEMVHKAVVEVDESGTRAAAATGT 368

  Fly   336 AVTNRAG--FSTFLMADHPFAFVIRDANTIYFQGRVVSP 372
            ..|.|:.  .|..|:.:.||...|.| |.|.|.|:|..|
Human   369 IFTFRSARLNSQRLVFNRPFLMFIVD-NNILFLGKVNRP 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Dd	NP_001163067.1	SERPIN	16..369	CDD:238101	114/359 (32%)
SERPINA5	NP_000615.3	alpha-1-antitrypsin_like	44..403	CDD:239011	114/359 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010