DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Dd and SERPINA2

DIOPT Version :9

Sequence 1:	NP_001163067.1	Gene:	Spn42Dd / 49808	FlyBaseID:	FBgn0028988	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_006211.2	Gene:	SERPINA2 / 390502	HGNCID:	8985	Length:	421	Species:	Homo sapiens

Alignment Length:	372	Identity:	102/372 - (27%)
Similarity:	178/372 - (47%)	Gaps:	19/372 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VTSVACQTSKEIYQLLSKSHTNQNLVVSPVSIETILSMVFMGAEGSTAKELQSALGLP-SEDKEA 73
            ||.:|....||:..|...|    |::|:|.|:....:|:.:|.:..|..|:...|.:. :|..||
Human    57 VTDLAFDLYKELADLSQTS----NVLVTPTSVAMAFAMLSLGTKADTRTEILEGLNVNLTETPEA 117

  Fly    74 -VAARYGALLNDLQGQEEGPILKLANRIYVNDQYSLNQNYNLAVREPFKSEAESISLTNGPVAAE 137
             :...:..:|..|...:....|...:.::||....|...:....::.:.|||.||:..:...|.|
Human   118 KIHECFQQVLQALSRPDTRLQLTTGSSLFVNKSMKLVDTFLEDTKKLYHSEASSINFRDTEEAKE 182

  Fly   138 RINQWVLDQTSGKIKGMIDPGSMTSDVKALLVNAIYFKGQWESKFDPAKTRASTFQVTANKSVPV 202
            :||.:|..:|..|:..::.  .:..|....||:.|.|.|:|:.||.........|.|.....:.|
Human   183 QINNYVEKRTGRKVVDLVK--HLKKDTSLALVDYISFHGKWKDKFKAEHIMVEGFHVDDKTIIRV 245

  Fly   203 QMMAQMGTFRANYFRDLDAQVIELPYLNSNLSMTIFLPREVEGLSALEEKIV-----GFARPLVA 262
            .|:..:|.|..:..|:|.:.|:...|: .|.:....|| :.:.:..||||:.     ...|....
Human   246 PMINHLGRFDIHRDRELSSWVLAQHYV-GNATAFFILP-DPKKMWQLEEKLTYSHLENIQRAFDI 308

  Fly   263 KEVYLKLPKFKIEFRDELKETLEKLGIRELFTDKSDLSGLFADKSGGKVSQVSHKAFLEVNEEGA 327
            :.:.|..||..|....:||..|..|||.::|::::||||: :.::..|:|:..|.|.|.::|:|.
Human   309 RSINLHFPKLSISGTYKLKRVLRNLGITKIFSNEADLSGV-SQEAPLKLSKAVHVAVLTIDEKGT 372

  Fly   328 EAAGATSVAVTNRAGFSTFLMADHPFAFVIRD--ANTIYFQGRVVSP 372
            ||.||..:.....:.:.| :|.:.||..:|:|  .|...|.|:||:|
Human   373 EATGAPHLEEKAWSKYQT-VMFNRPFLVIIKDDITNFPLFIGKVVNP 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Dd	NP_001163067.1	SERPIN	16..369	CDD:238101	96/361 (27%)
SERPINA2	NP_006211.2	SERPIN	62..418	CDD:214513	98/365 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010