DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Dd and Serpinb3a

DIOPT Version :9

Sequence 1:	NP_001163067.1	Gene:	Spn42Dd / 49808	FlyBaseID:	FBgn0028988	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_033152.3	Gene:	Serpinb3a / 20248	MGIID:	3573933	Length:	387	Species:	Mus musculus

Alignment Length:	377	Identity:	137/377 - (36%)
Similarity:	204/377 - (54%)	Gaps:	27/377 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EIYQLLSKSHTNQNLVVSPVSIETILSMVFMGAEGSTAKELQSAL------------GLPSEDKE 72
            |:|:.|.:|  :.|:..||:|:.|.|:|:.:||:|:|.|:::..|            .....|:|
Mouse    14 ELYRQLRES--DNNIFYSPISMMTALAMLQLGAKGNTEKQIEKVLQFNETTKKTTEKSAHCHDEE 76

  Fly    73 AVAARYGALLNDLQGQEEGPILKLANRIYVNDQYSLNQNYNLAVREPFKSEAESISLTNGPVAAE 137
            .|..::..|:..|....:...||.||.||....:...|.:...::|.:::..||:...:....:|
Mouse    77 NVHEQFQKLMTQLNKSNDAYDLKAANSIYGAKGFPFVQTFLEDIKEYYQANVESLDFEHAAEESE 141

  Fly   138 -RINQWVLDQTSGKIKGMIDPGSMTSDVKALLVNAIYFKGQWESKFDPAKTRASTFQVTANKSVP 201
             :||.||..||:||||.:...||:......:||||:||||||..|||...|....|.:..|.|.|
Mouse   142 KKINSWVESQTNGKIKDLFPNGSLNRSTIMVLVNAVYFKGQWNHKFDEKHTTEEKFWLNKNTSKP 206

  Fly   202 VQMMAQMGTFRANYFRDLDAQVIELPYLNSNLSMTIFLPREVEGLSALEEKIVG-------FARP 259
            ||||.|...|...:..|:.|:::|:||....|||.:.||.|:.||..|||::..       .|..
Mouse   207 VQMMKQNIEFNFMFLEDVQAKIVEIPYKGKELSMIVLLPVEINGLKQLEEQLTADKLLEWTRAEN 271

  Fly   260 LVAKEVYLKLPKFKIEFRDELKETLEKLGIRELF-TDKSDLSGLFADKSGGKVSQVSHKAFLEVN 323
            :...|:||.||:||::.:.:|...||.:|:.:.| ..|:|.||: :...|..||:|.||:|:|||
Mouse   272 MHMTELYLSLPRFKVDEKYDLPIPLEHMGMVDAFDPQKADFSGM-SSTQGLVVSKVLHKSFVEVN 335

  Fly   324 EEGAEAAGATSVAVT-NRAGFSTFLMADHPFAFVI--RDANTIYFQGRVVSP 372
            |||.|||.||.|.|: ..|..:.....||||.|.|  |..|:|.|.||:.||
Mouse   336 EEGTEAAAATGVEVSLTSAQIAEDFCCDHPFLFFIIHRKTNSILFFGRISSP 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Dd	NP_001163067.1	SERPIN	16..369	CDD:238101	134/372 (36%)
Serpinb3a	NP_033152.3	SERPIN	5..387	CDD:294093	135/375 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	216	1.000	Domainoid score	I2692
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H76659
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3582
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		otm44262
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.880