Protein Alignment Spn42Dd and SERPINA12

DIOPT Version :10

• Sequence 1: NP_001163067.1
• Gene: Spn42Dd / 49808
• FlyBaseID: FBgn0028988
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_776249.1
• Gene: SERPINA12 / 145264
• HGNCID: 18359
• Length: 414
• Species: Homo sapiens
• Alignment Length: 392
• Identity: 101/392 - (25%)
• Similarity: 195/392 - (49%)
• Gaps: 47/392 - (11%)

  Fly     9 WVTSVACQTSKEI--------YQLLSK---SHTNQNLVVSPVSIETILSMVFMGAEGSTAKELQS 62
            |...:|   :||:        ::||.|   .:..:|:.:||:||.|..||:.:||:.||..|::.
Human    39 WKQRMA---AKELARQNMDLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQ 100

  Fly    63 ALGLPSEDKEAVAARYGALLNDLQGQEEGPILKLANRIYVNDQYSLNQNYNLAVREPFKSEAESI 127
            ........::.:...:..::::|..:.:...|.:.|.::::.:....:.:....:..:.:|....
Human   101 GFNFRKMPEKDLHEGFHYIIHELTQKTQDLKLSIGNTLFIDQRLQPQRKFLEDAKNFYSAETILT 165

  Fly   128 SLTNGPVAAERINQWVLDQTSGKIKGM---IDPGSMTSDVKALLVNAIYFKGQWESKFDPAKTRA 189
            :..|..:|.::||.::..:|.|||..:   ||||::     .||.|.|:|:.:|:.:|||..|:.
Human   166 NFQNLEMAQKQINDFISQKTHGKINNLIENIDPGTV-----MLLANYIFFRARWKHEFDPNVTKE 225

  Fly   190 STFQVTANKSVPVQMMAQMGTFRANYFRDLDAQVIELPYLNSNLSMTIFLPREVEGLSALEE--K 252
            ..|.:..|.||.|.||.:.|.::..|...|...::|:|| ..|::....||.|.: |..||:  :
Human   226 EDFFLEKNSSVKVPMMFRSGIYQVGYDDKLSCTILEIPY-QKNITAIFILPDEGK-LKHLEKGLQ 288

  Fly   253 IVGFAR--PLVAKEVY-LKLPKFKIEFRDELKETLEKLGIRELFTDKSDLSGLFADKSGGKVSQV 314
            :..|:|  .|:::.|. :.:|:..:....:||:||..:|:.::|.:..||:.:...:| .||.:.
Human   289 VDTFSRWKTLLSRRVVDVSVPRLHMTGTFDLKKTLSYIGVSKIFEEHGDLTKIAPHRS-LKVGEA 352

  Fly   315 SHKAFLEVNEEGAEAAGATSVAVTNRAGFSTFLM-------ADHPFAFVIRDAN--TIYFQGRVV 370
            .|||.|:::|.|.|.|..|        |..|..|       .|.|:..:|....  ::.|.|::|
Human   353 VHKAELKMDERGTEGAAGT--------GAQTLPMETPLVVKIDKPYLLLIYSEKIPSVLFLGKIV 409

  Fly   371 SP 372
            :|
Human   410 NP 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Dd	NP_001163067.1	serpin42Dd-like_insects	12..372	CDD:381070	99/387 (26%)
SERPINA12	NP_776249.1	serpinA12_vaspin	40..411	CDD:381026	99/389 (25%)
		Reactive center loop. /evidence=ECO:0000269|PubMed:26529565, ECO:0000305|PubMed:23370777, ECO:0000305|PubMed:26199422	364..382		7/25 (28%)