DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and SERPINB12

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	XP_005266835.2	Gene:	SERPINB12 / 89777	HGNCID:	14220	Length:	437	Species:	Homo sapiens

Alignment Length:	423	Identity:	133/423 - (31%)
Similarity:	216/423 - (51%)	Gaps:	64/423 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVL----------KL 66
            :.:.:|..|.:|.:.|::...|:..||||:..||.|..:|||:.:|.::..||          |.
Human    18 TANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLHFNEFSQNESKE 82

  Fly    67 PD-----DKKEVAAK------------------------------YKDLLSKLEGREKVATLSLA 96
            ||     :|::|.|.                              :..|||||:..:...|||:|
Human    83 PDPCLKSNKQKVLADSSLEGQKKTTEPLDQQAGSLNNESGLVSCYFGQLLSKLDRIKTDYTLSIA 147

  Fly    97 NRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDI-VDPNKASSIVNNWVDNQTRGKIKDLVSSNDM- 159
            ||:|..::|.:...|...|...:....|::|. .:|.|:...:|.||:.|::||||:|.|.:.:
Human   148 NRLYGEQEFPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEINFWVECQSQGKIKELFSKDAIN 212

  Fly   160 SKMELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVPVEMMSLFQSFRAAHDSELGAKIIEL 224
            ::..|:::||:|||.:||..|:.:.|....|.::..::..|:||:....:|.....|:.|:|:|:
Human   213 AETVLVLVNAVYFKAKWETYFDHENTVDAPFCLNANENKSVKMMTQKGLYRIGFIEEVKAQILEM 277

  Fly   225 PYRNSSLSMLIFLP----DQVDGLSELEKKIVGFK-------PKLSKMDVTLRLPKFKIEFFAQL 278
            .|....|||.:.||    |.:.||.|||:||...|       ..:|:..|.|..|:|.:|....|
Human   278 RYTKGKLSMFVLLPSHSKDNLKGLEELERKITYEKMVAWSSSENMSEESVVLSFPRFTLEDSYDL 342

  Fly   279 NKVLVAMGIQDAFEKS-ADFKDLVENSNVHVKKVIHKAFIEVNEEGAEAAAATALLFVRYSMPMP 342
            |.:|..|||.|.|::: ||...:..:.|:::.|:|||.|:||:|.|.:|||||..:....|:
Human   343 NSILQDMGITDIFDETRADLTGISPSPNLYLSKIIHKTFVEVDENGTQAAAATGAVVSERSL--- 404

  Fly   343 SSQMVFNADHPFAYVIRDR--ETIYFQGHFVKP 373
            .|.:.|||:|||.:.||..  :||.|.|....|
Human   405 RSWVEFNANHPFLFFIRHNKTQTILFYGRVCSP 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	132/416 (32%)
SERPINB12	XP_005266835.2	ovalbumin_like	16..437	CDD:239014	132/421 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2614
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	222	1.000	Inparanoid score	I3541
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.980