DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and SERPINH1

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001193943.1	Gene:	SERPINH1 / 871	HGNCID:	1546	Length:	418	Species:	Homo sapiens

Alignment Length:	372	Identity:	102/372 - (27%)
Similarity:	176/372 - (47%)	Gaps:	21/372 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVL---KLPDDKKEVAA 75
            |...|...||.:||:.|..|::.||:.|..:|.:..:|.:|.||.:.:.||   :|.|:  ||.|
Human    47 SAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDE--EVHA 109

  Fly    76 KYKDLLSKL-EGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDPNKASSIVN 139
            ...:||..| ....:..|..|.:|:|..........:.:..|..:..|...|:..|...|...:|
Human   110 GLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSIN 174

  Fly   140 NWVDNQTRGKIKDLVSSNDMSKMELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVPVEMMS 204
            .|....|.||:.::....:.:...|:| ||::||..|:.||:.|:...|.|.|:...:|.|.||.
Human   175 EWAAQTTDGKLPEVTKDVERTDGALLV-NAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMH 238

  Fly   205 LFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVDGLSELEKKIVG-----FKPKLSKMDVT 264
            ....:....|.:...:|:|:|..:...|::|.:|..|:.|..|||.:..     :..|:.|..|.
Human   239 RTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVA 303

  Fly   265 LRLPKFKIEFFAQLNKVLVAMGIQDAFEKS-ADFKDLVENSNVHVKKVIHKAFIEVNEEGAEAAA 328
            :.|||..:|....|.|.|..:|:.:|.:|: ||...:....::::..|.|....|::.:|.....
Human   304 ISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNPFDQ 368

  Fly   329 ATALLFVRYSMPMPSSQMVFNADHPFAYVIRDRE--TIYFQGHFVKP 373
            .   ::.|..:..|.   :|.|||||.:::||.:  ::.|.|..|:|
Human   369 D---IYGREELRSPK---LFYADHPFIFLVRDTQSGSLLFIGRLVRP 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	100/367 (27%)
SERPINH1	NP_001193943.1	serpinH1_CBP1	36..417	CDD:381003	102/372 (27%)
SERPINH1	NP_001193943.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920