DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and Serpind1

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_077358.1	Gene:	Serpind1 / 79224	RGDID:	619854	Length:	479	Species:	Rattus norvegicus

Alignment Length:	377	Identity:	114/377 - (30%)
Similarity:	201/377 - (53%)	Gaps:	25/377 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VSCRFADDFYQLLAKE-NAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKLPD-----DKK 71
            ::.:||.:.|::|..: .:::|:..:|:.:..|:.|..:|.|.:|.:|:.:||...|     .|.
  Rat   109 LNAKFAFNLYRVLKDQATSSDNIFIAPVGISTAMGMISLGLRGETHEEVHSVLHFKDFVNASSKY 173

  Fly    72 EVAA---KYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDPNK 133
            ||..   .::.|..:|..|....||...|.:|:.|:|.:...:...:::.:.|||:..|..||..
  Rat   174 EVTTIHNLFRKLTHRLFRRNFGYTLQSVNDLYIQKQFPIREDFKAAMREFYFAEAQEADFSDPAF 238

  Fly   134 ASSIVNNWVDNQTRGKIKDLVSSNDMSKMELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKSV 198
            .|. .|:.:...|:|.||:.:.:.| |..::::||.|||||.|..||..::|...|||:::::.|
  Rat   239 ISK-ANSHILKLTKGLIKEALENTD-SATQMMILNCIYFKGAWMNKFPVEMTHNHNFRLNEREVV 301

  Fly   199 PVEMMSLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVDGLSELEKKIV-----GFKPKL 258
            .|.||....:|.||:|.||...|::|.| ...:||||.:|.::.|:..||.::.     .::..:
  Rat   302 KVSMMQTKGNFLAANDQELDCDILQLEY-VGGISMLIVIPRKLSGMKTLEAQLTPQVVERWQKSM 365

  Fly   259 SKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEKSADFKDLVENSNVHVKKVIHKAFIEVNEEG 323
            :.....:.|||||:|....|.:||.:|||...|.|:.:... :.:..:.:....|::.|.|||||
  Rat   366 TNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSG-ISDQRIIIDLFKHQSTITVNEEG 429

  Fly   324 AEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDRET--IYFQGHFVKP 373
            .:|||.|.:.|    ||: |:|:.|..|.||.:::.:..|  :.|.|....|
  Rat   430 TQAAAVTTVGF----MPL-STQVRFTVDRPFLFLVYEHRTSCLLFMGRVANP 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	113/371 (30%)
Serpind1	NP_077358.1	HCII	44..477	CDD:239002	114/377 (30%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	55..79
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	172..192		5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020