DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn28F and SERPINA7

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	XP_006724746.1	Gene:	SERPINA7 / 6906	HGNCID:	11583	Length:	425	Species:	Homo sapiens

Alignment Length:	397	Identity:	105/397 - (26%)
Similarity:	180/397 - (45%)	Gaps:	47/397 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVL--KLPDDKK-E 72
            :|::..||.:.|:....|....|:..||:|:..||.|...||...|..|:...|  .|.|... |
Human    43 SSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVE 107

  Fly    73 VAAKYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDPNKASSI 137
            :...::.|:..|...:|...|.:.|.:::.|..:.:..:...||..:..|..:.|..:.:.|...
Human   108 IQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQE 172

  Fly   138 VNNWVDNQTRGKIKDLVSSNDMSKMELIVL-NAIYFKGQWEYKFNPKLTK-KRNFRVSDQKSVPV 200
            :|:.|:.||:||:..|:  .|:....::|| |.|:||.||...|:|..|: ..:|.:....:|.|
Human   173 INSHVEMQTKGKVVGLI--QDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQV 235

  Fly   201 EMMSLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLP--DQVDGLSEL--EKKIVGFKPKLSKM 261
            .||...:.:....|.||...::::.|..::|::.: ||  .|::.:...  .|.:..:...|.|.
Human   236 PMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFV-LPKEGQMESVEAAMSSKTLKKWNRLLQKG 299

  Fly   262 DVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEKSADFKDLVENSNVHVK----------KVIHKAF 316
            .|.|.:|||.|.....|...|:.||||.|:.::|||..|.|::.:.:.          :..|||.
Human   300 WVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNRPAGFVLPTQAAHKAV 364

  Fly   317 IEVNEEGAEAAAATALLFVRYSMPMPSSQM-----------VFNADHPFAYVIRDRET--IYFQG 368
            :.:.|:|.||||            :|..::           :...|..|..:|.:|.|  |.|.|
Human   365 LHIGEKGTEAAA------------VPEVELSDQPENTFLHPIIQIDRSFMLLILERSTRSILFLG 417

  Fly   369 HFVKPNE 375
            ..|.|.|
Human   418 KVVNPTE 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	101/387 (26%)
SERPINA7	XP_006724746.1	alpha-1-antitrypsin_like	46..419	CDD:239011	101/387 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010