DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and SERPINE3

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001094790.1	Gene:	SERPINE3 / 647174	HGNCID:	24774	Length:	424	Species:	Homo sapiens

Alignment Length:	401	Identity:	107/401 - (26%)
Similarity:	179/401 - (44%)	Gaps:	53/401 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HLCLLLL-------ATSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEM 60
            |.|.|..       .|.:...||...||.:|......|.:.||..|.:.|.:...||...|.|::
Human    12 HSCCLRANGHLREGMTLLKTEFALHLYQSVAACRNETNFVISPAGVSLPLEILQFGAEGSTGQQL 76

  Fly    61 RNVLKLPDDKKEVA----AKYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMA 121
            .:.|......|.|.    |.|..|.:..:|.|    :.||..::|.....|.|.:.:.|.....:
Human    77 ADALGYTVHDKRVKDFLHAVYATLPTSSQGTE----MELACSLFVQVGTPLSPCFVEHVSWWANS 137

  Fly   122 EAEAIDIVDPNKASSIVNNWVDNQTRGKIK---------DLVSSNDMSKMELIVLNAIYFKGQWE 177
            ..|..|:.:||..:...:.....:|.|...         :.||:   :..:|::::.:.|:|.|.
Human   138 SLEPADLSEPNSTAIQTSEGASRETAGGGPSEGPGGWPWEQVSA---AFAQLVLVSTMSFQGTWR 199

  Fly   178 YKFNPKLTKKRNFRVSDQKSVPVEMMSL-----FQSFRAAHDSELGAKIIELPYRNSSLSMLIFL 237
            .:|:...|:...|..:....:.|.||..     :..|:.....::|  ::||||..|::|:.:.|
Human   200 KRFSSTDTQILPFTCAYGLVLQVPMMHQTTEVNYGQFQDTAGHQVG--VLELPYLGSAVSLFLVL 262

  Fly   238 P-DQVDGLSELEKKIVGFKPKL-------SKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEK- 293
            | |:...||.:|..:......|       ::|||.  ||:|:|:....|..:|.:.|:.|.|:.
Human   263 PRDKDTPLSHIEPHLTASTIHLWTTSLRRARMDVF--LPRFRIQNQFNLKSILNSWGVTDLFDPL 325

  Fly   294 SADFKDLVENSNVHVKKVIHKAFIEVNEEGAEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVI 358
            .|:.|.:......:|.:.||||.|||.|||.:|:.|||||.::.|. :|    :|.||.||.|.:
Human   326 KANLKGISGQDGFYVSEAIHKAKIEVLEEGTKASGATALLLLKRSR-IP----IFKADRPFIYFL 385

  Fly   359 RDRE---TIYF 366
            |:..   |::|
Human   386 REPNTGITVFF 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	103/383 (27%)
SERPINE3	NP_001094790.1	SERPIN	31..399	CDD:238101	103/382 (27%)
SERPINE3	NP_001094790.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..174		5/30 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020