DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn28F and SERPINB4

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_002965.1	Gene:	SERPINB4 / 6318	HGNCID:	10570	Length:	390	Species:	Homo sapiens

Alignment Length:	392	Identity:	134/392 - (34%)
Similarity:	210/392 - (53%)	Gaps:	35/392 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVL---KLPDDKKE 72
            :..:.:|..|.:|...| :..||:..||:|:..||.|..:||:..|||::..||   ::.::..|
Human     5 SEANTKFMFDLFQQFRK-SKENNIFYSPISITSALGMVLLGAKDNTAQQISKVLHFDQVTENTTE 68

  Fly    73 VAAKY------------KDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEA 125
            .||.|            :.||::.........|.:||:::..|.:|.:..|...:|..:....|:
Human    69 KAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYQFLQEYLDAIKKFYQTSVES 133

  Fly   126 IDIVD-PNKASSIVNNWVDNQTRGKIKDL----VSSNDMSKMELIVLNAIYFKGQWEYKFNPKLT 185
            .|..: |.::...:|:||::||..|||:|    ...||.:   |:::||||||||||.||..:.|
Human   134 TDFANAPEESRKKINSWVESQTNEKIKNLFPDGTIGNDTT---LVLVNAIYFKGQWENKFKKENT 195

  Fly   186 KKRNFRVSDQKSVPVEMMSLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVDGLSELEKK 250
            |:..|..:......|:||..:.||..|...::.||::|:||:...|||::.||:::|||.:||:|
Human   196 KEEKFWPNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEK 260

  Fly   251 IVGFK-------PKLSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEKSADFKDLVENSNVHV 308
            :...|       ..:.:..|.|.||:||:|....|...|..||:.:.|...||...:..:..:.|
Human   261 LTAEKLMEWTSLQNMRETCVDLHLPRFKMEESYDLKDTLRTMGMVNIFNGDADLSGMTWSHGLSV 325

  Fly   309 KKVIHKAFIEVNEEGAEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDRET--IYFQGHFV 371
            .||:||||:||.|||.|||||||::.|..|  .||:...|..:|||.:.||..:|  |.|.|.|.
Human   326 SKVLHKAFVEVTEEGVEAAAATAVVVVELS--SPSTNEEFCCNHPFLFFIRQNKTNSILFYGRFS 388

  Fly   372 KP 373
            .|
Human   389 SP 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	132/384 (34%)
SERPINB4	NP_002965.1	SERPIN	4..390	CDD:320777	133/390 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2614
eggNOG	1	0.900	-	-		E33208_3B998
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H76659
Inparanoid	1	1.050	222	1.000	Inparanoid score	I3541
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.780