DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and SERPINI2

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001012303.2	Gene:	SERPINI2 / 5276	HGNCID:	8945	Length:	405	Species:	Homo sapiens

Alignment Length:	393	Identity:	116/393 - (29%)
Similarity:	205/393 - (52%)	Gaps:	30/393 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LCLLLLATSVS-C------RFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMR 61
            |.||...:..| |      .||.|.||.::..: .:|:|.|||.:.:.|.|..:||:.|..|::|
Human     9 LLLLFFGSQASRCSAQKNTEFAVDLYQEVSLSH-KDNIIFSPLGITLVLEMVQLGAKGKAQQQIR 72

  Fly    62 NVLKLPDDKKEVAA-----KYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMA 121
            ..||    ::|.:|     ..|...|.:..:::..|.:|||.:|:.:.|.:...|....|:.|.:
Human    73 QTLK----QQETSAGEEFFVLKSFFSAISEKKQEFTFNLANALYLQEGFTVKEQYLHGNKEFFQS 133

  Fly   122 EAEAIDIVDPNKASSIVNNWVDNQTRGKIKDLVSSNDMSKM-ELIVLNAIYFKGQWEYKFNPKLT 185
            ..:.:|..|....:.:::.||:.:|.|||||:.|..:...: .|:::|||||||.|:.||..:.|
Human   134 AIKLVDFQDAKACAEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLVNAIYFKGDWKQKFRKEDT 198

  Fly   186 KKRNFRVSDQKSVPVEMMS--LFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVDGLSELE 248
            :..||...:..:|.:.||.  |...:....:|.|..:::||.|:....|::|.||.:...:.|:|
Human   199 QLINFTKKNGSTVKIPMMKALLRTKYGYFSESSLNYQVLELSYKGDEFSLIIILPAEGMDIEEVE 263

  Fly   249 K-----KIVGFKPKLSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEKSADFKDLVENSNVHV 308
            |     :|:.:..::.:.:|.:.||:||:|.......||.::.|.:.|....|...:.::|.|:|
Human   264 KLITAQQILKWLSEMQEEEVEISLPRFKVEQKVDFKDVLYSLNITEIFSGGCDLSGITDSSEVYV 328

  Fly   309 KKVIHKAFIEVNEEGAEAAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDR--ETIYFQGHFV 371
            .:|..|.|.|:||:|:|||.:|.   :...:.|..:|..|.|:|||.::::..  |:|.|.|...
Human   329 SQVTQKVFFEINEDGSEAATSTG---IHIPVIMSLAQSQFIANHPFLFIMKHNPTESILFMGRVT 390

  Fly   372 KPN 374
            .|:
Human   391 NPD 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	112/377 (30%)
SERPINI2	NP_001012303.2	serpinI2_pancpin	23..392	CDD:381042	110/376 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3483
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.960