DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and SERPINB10

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_005015.1	Gene:	SERPINB10 / 5273	HGNCID:	8942	Length:	397	Species:	Homo sapiens

Alignment Length:	399	Identity:	130/399 - (32%)
Similarity:	217/399 - (54%)	Gaps:	39/399 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LATSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKL------- 66
            ||||:: :||.:..:.||:.....|:..|..|:..:|::.|:||:..||.:|..||:.
Human     4 LATSIN-QFALELSKKLAESAQGKNIFFSSWSISTSLTIVYLGAKGTTAAQMAQVLQFNRDQGVK 67

  Fly    67 --PDDKK------------EVAAKYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKD 117
              |:.:|            |:.:.::.|:|::........|..||.||..|.:.....|.:.:|.
Human    68 CDPESEKKRKMEFNLSNSEEIHSDFQTLISEILKPNDDYLLKTANAIYGEKTYAFHNKYLEDMKT 132

  Fly   118 SFMAEAEAIDIVD-PNKASSIVNNWVDNQTRGKIKDLVSSNDM-SKMELIVLNAIYFKGQWEYKF 180
            .|.||.:.::.|: .::....:|:||:.||.|||::|:..:.: |...:|::||:||||.||::|
Human   133 YFGAEPQPVNFVEASDQIRKDINSWVERQTEGKIQNLLPDDSVDSTTRMILVNALYFKGIWEHQF 197

  Fly   181 NPKLTKKRNFRVSDQKSVPVEMMSLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVDGLS 245
            ..:.|.::.||:::..|.||:||.:.:.....|..:..|..::|.|::..||:||.||:.::||.
Human   198 LVQNTTEKPFRINETTSKPVQMMFMKKKLHIFHIEKPKAVGLQLYYKSRDLSLLILLPEDINGLE 262

  Fly   246 ELEKKIVGFK-------PKLSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEKS-ADFKDLVE 302
            :|||.|...|       ..:...:|.|.|||||:|....|...|.:||:.|||.:| |||..:..
Human   263 QLEKAITYEKLNEWTSADMMELYEVQLHLPKFKLEDSYDLKSTLSSMGMSDAFSQSKADFSGMSS 327

  Fly   303 NSNVHVKKVIHKAFIEVNEEGAEAAAAT-ALLFVRYSMPMPSSQMVFNADHPFAYVIRDRE--TI 364
            ..|:.:..|.||||:|:||:|.||||.: :.:.:|..:|    .:.|||:|||.:.||..:  ||
Human   328 ARNLFLSNVFHKAFVEINEQGTEAAAGSGSEIDIRIRVP----SIEFNANHPFLFFIRHNKTNTI 388

  Fly   365 YFQGHFVKP 373
            .|.|....|
Human   389 LFYGRLCSP 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	125/389 (32%)
SERPINB10	NP_005015.1	PAI-2	4..397	CDD:239013	129/397 (32%)
SERPINB10	NP_005015.1	Nuclear localization signal	74..77		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3483
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.860