DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn28F and SERPINB9

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_004146.1	Gene:	SERPINB9 / 5272	HGNCID:	8955	Length:	376	Species:	Homo sapiens

Alignment Length:	375	Identity:	124/375 - (33%)
Similarity:	212/375 - (56%)	Gaps:	15/375 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLKLPDDKKEVAA 75
            ::.|..||....::|.::|.::|:..||:|:..||:|..:||:..||.:|...|.| :.::::..
Human     5 SNASGTFAIRLLKILCQDNPSHNVFCSPVSISSALAMVLLGAKGNTATQMAQALSL-NTEEDIHR 68

  Fly    76 KYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIVDPNKAS-SIVN 139
            .::.||:::........|..|||::..|..|.:.::.:.....:.||.:.:..:...:.| ..:|
Human    69 AFQSLLTEVNKAGTQYLLRTANRLFGEKTCQFLSTFKESCLQFYHAELKELSFIRAAEESRKHIN 133

  Fly   140 NWVDNQTRGKIKDLVSSNDM-SKMELIVLNAIYFKGQWEYKFNPKLTKKRNFRVSDQKSVPVEMM 203
            .||..:|.|||::|:..:.: ::..|:::|||||||:|...|:...|::..|:::.::..||:||
Human   134 TWVSKKTEGKIEELLPGSSIDAETRLVLVNAIYFKGKWNEPFDETYTREMPFKINQEEQRPVQMM 198

  Fly   204 SLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVDGLSELEK-----KIVGF-KPKLSK-M 261
            ....:|:.||..|:.|:::||||....||:|:.|||....||.:||     |:..: ||...| .
Human   199 YQEATFKLAHVGEVRAQLLELPYARKELSLLVLLPDDGVELSTVEKSLTFEKLTAWTKPDCMKST 263

  Fly   262 DVTLRLPKFKIEFFAQLNKVLVAMGIQDAFEK-SADFKDLVENSNVHVKKVIHKAFIEVNEEGAE 325
            :|.:.|||||::....:..||..:||.|||:: .||...:....::.:.|.:||:|:||||||.|
Human   264 EVEVLLPKFKLQEDYDMESVLRHLGIVDAFQQGKADLSAMSAERDLCLSKFVHKSFVEVNEEGTE 328

  Fly   326 AAAATALLFVRYSMPMPSSQMVFNADHPFAYVIRDR--ETIYFQGHFVKP 373
            ||||:: .||.....|.|... |.|||||.:.||..  .:|.|.|.|..|
Human   329 AAAASS-CFVVAECCMESGPR-FCADHPFLFFIRHNRANSILFCGRFSSP 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	122/367 (33%)
SERPINB9	NP_004146.1	SERPIN	4..376	CDD:320777	123/373 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.930