DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28F and SERPINB8

DIOPT Version :9

Sequence 1:	NP_524957.2	Gene:	Spn28F / 49807	FlyBaseID:	FBgn0028987	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001353127.1	Gene:	SERPINB8 / 5271	HGNCID:	8952	Length:	374	Species:	Homo sapiens

Alignment Length:	387	Identity:	135/387 - (34%)
Similarity:	209/387 - (54%)	Gaps:	27/387 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKHLCLLLLATSVSCRFADDFYQLLAKENAANNLISSPLSVEIALSMAYMGARAKTAQEMRNVLK 65
            |..||      ..:..||...:::|.:|:.:.|:..||:|:..||:|.:|||:..||.:|...|.
Human     1 MDDLC------EANGTFAISLFKILGEEDNSRNVFFSPMSISSALAMVFMGAKGSTAAQMSQALC 59

  Fly    66 LPDDKKEVAAKYKDLLSKLEGREKVATLSLANRIYVNKKFQLVPSYNQMVKDSFMAEAEAIDIV- 129
            |..| .::...::.|||::........|..|||::..|....:|.:.:..:..:.||.|.:...
Human    60 LYKD-GDIHRGFQSLLSEVNRTGTQYLLRTANRLFGEKTCDFLPDFKEYCQKFYQAELEELSFAE 123

  Fly   130 DPNKASSIVNNWVDNQTRGKIKDLVSSNDMSKM-ELIVLNAIYFKGQWEYKFNPKLTKKRNFRVS 193
            |..:....:|:||..:|.|||.:::.:..:..: :|:::|||||||:|..:|:.|.|:...|:.:
Human   124 DTEECRKHINDWVAEKTEGKISEVLDAGTVDPLTKLVLVNAIYFKGKWNEQFDRKYTRGMLFKTN 188

  Fly   194 DQKSVPVEMMSLFQSFRAAHDSELGAKIIELPYRNSSLSMLIFLPDQVDGLSELEKKIV--GFK- 255
            ::|.. |:||.....|:..:..|:..:::||||....|||:|.|||....|:.:||.:.  .||
Human   189 EEKKT-VQMMFKEAKFKMGYADEVHTQVLELPYVEEELSMVILLPDDNTDLAVVEKALTYEKFKA 252

  Fly   256 ----PKLSKMDVTLRLPKFKIEFFAQLNKVLVAMGIQDAF-EKSADFKDLVENSNVHVKKVIHKA 315
                .||:|..|.:.||:.|:|....|...|..:|:.||| |..|||..:....||.:.||.||.
Human   253 WTNSEKLTKSKVQVFLPRLKLEESYDLEPFLRRLGMIDAFDEAKADFSGMSTEKNVPLSKVAHKC 317

  Fly   316 FIEVNEEGAEAAAATALLFVRYSMPMPSSQMV--FNADHPFAYVIRDRET--IYFQGHFVKP 373
            |:||||||.|||||||:  ||.|.   .|:|.  |.|||||.:.||..:|  |.|.|.|..|
Human   318 FVEVNEEGTEAAAATAV--VRNSR---CSRMEPRFCADHPFLFFIRHHKTNCILFCGRFSSP 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28F	NP_524957.2	SERPIN	14..370	CDD:238101	130/369 (35%)
SERPINB8	NP_001353127.1	SERPIN	4..374	CDD:320777	133/382 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.930